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Zocor (Simvastatin)
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Zocor

Zocor is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Zocor is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol (''bad cholesterol'') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol (''good cholesterol'') in the blood.

Other names for this medication:
Actalipid, Docsimvasta, Dosavastatin, Lipex, Lipinorm, Lodales, Normotherin, Simbastatin, Simgal, Simvastatin, Simvastatina, Simvastatinum, Simvofix, Sinvacor, Sivastin, Statinal, Vasilip, Zocord, Zorced, Zorstat, Zosta, Zostin, Zostine, Zovast, Zovastin, Zovatin, Zurocid

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Also known as: Simvastatin

Description

Zocor is an HMG-CoA reductase inhibitor. Zocor is used to: reduce the risk of heart attack, stroke, and death due to coronary heart disease; reduce the risk of heart attack, stroke, blood vessel blockage, or chest pain caused by angina; low high cholesterol and triglycerides; increase high-density lipoprotein (HDL, "good") cholesterol levels. Zocor is also known as Imvastatin, Simlup, Simcardis, Ranzolont, Simvador. Zocor works by reducing the production of certain fatty substances in the body, including cholesterol. Generic name of Zocor is Simvastatin. Brand name of Zocor is Zocor.

Dosage

Take Zocor orally. Take Zocor with or without food. Do not use grapefruit or grapefruit juice while taking Zocor. Eating grapefruit or drinking grapefruit juice may increase the amount of Zocor in blood, what may increase the serious side effects. If you want to achieve most effective results do not stop taking Zocor suddenly.

Overdose

If you overdose Zocor and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Zocor are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Zocor if you are allergic to Zocor components. Be careful with Zocor if you're pregnant or you plan to have a baby. Do not use it if you are a nursing mother. Be careful with Zocor if you suffer from low blood pressure, kidney problems, diabetes, serious infection, metabolism problems, hormonal problems. Do not use potassium supplements or salt substitutes. Avoid eating grapefruit or drinking grapefruit juice while taking Zocor. While taking Zocor, you can make laboratory tests (blood cholesterol levels, liver function tests, creatine phosphokinase blood levels) to monitor the condition of your health. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Be very careful when you are driving machine. Do not stop taking Zocor suddenly.

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Apaches and West African Negroes: blood types of Asiatic Indians and Apaches. Detection of Survivin-expressing circulating cancer cells in the peripheral blood of breast cancer patients by a RT-PCR ELISA. Despite major structural differences between these two receptor types and agonist-dependent phosphorylation of the muscarinic M3- but not gonadotropin-releasing hormone receptor, signalling by both receptors was similarly inhibited by expression of either RGS2 or RGS3, whereas RGS4 has little effect. Warming strengthened trophic cascades from fish to primary producers, and it decreased the impact of eutrophication on the mean and temporal variation of phytoplankton biomass. Long iliac artery occlusions, in particular, if associated with common femoral artery pathology and long superficial femoral artery occlusions crossing the knee joint so far remain a domain of surgery. Pediatric emergency medicine--an evolving sub-speciality in Pakistan. Experience with profound hypothermia and circulatory arrest in the treatment of aneurysms of the aortic arch. A mixed-model analysis of variance was fitted to gene expression data and model signatures to assess the statistical significance of observed variations within and between samples and disease states. We describe a method for quantifying the mechanical properties of cells in suspension with a microfluidic device consisting of a parallel array of micron-sized constrictions. Incidence and natural course of symptomatic central serous chorioretinopathy in pregnant women in a maternity hospital in Kuwait.

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Acetochlor had a stronger acute toxic effect on the earthworms than methamidophos. Combination of these two drugs had an additive effect on the reduction of arterial pressure and organ vascular resistances. Testicular dysfunction may be present before the onset of testicular hypotrophy. Our calculations suggest that if electrodes could be constructed to have negligible dimensions compared with those in use today, we would increase resolution by about one order of magnitude at most. Pre- and post-evaluation of clinical outcomes and knowledge translation strategies associated with implementing the second stage of labor clinical practice guideline at two birthing units within a large teaching hospital. Radiographic indicators of traumatic cervical spine instability. The data suggest that exposure to mining irritants may result in disorders of lung function, and that this effect is greater in cigarette smokers. We present a case of CPN palsy in a 50-year-old immunocompetent man with no other comorbid medical condition secondary to peroneus longus abscess. The full Kullback-Leibler support of the proposed process is provided.

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A nonparametric regression-based linkage scan of rheumatoid factor-IgM using sib-pair squared sums and differences. This new approach requires the team to share key elements, such as the electronic record, the organization of care for different population groups, quality systems, and consultations among professionals in the same center. The relationship between NC and other epidermal nevi in which EH may occur is further emphasized by this finding. The disc herniation can be extracted via this lamina fenestration. Naloxone and phentolamine produced a recovery of oral tissue blood flow with and without systemic hemodynamic recovery, respectively. Simulated virtual screening experiments with the MDL Drug Data Report and maximum unbiased validation data sets show that the use of ligand expansion provides a very simple way of improving the LBVS, especially when the active molecules being sought have a high degree of structural heterogeneity.

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miR-203 expression levels were downregulated in NSCLC tissues while Bmi1 expression was upregulated in NSCLC tissues and cell lines. In rats with renal hypertension the activation of noradrenergic neurons in the hypothalamus was due to exhaustion of NA stores with normal amount of DA, but still the adrenergic neurons were activated. If these clinical criteria had been applied to the patients under investigation, the number of chest roentgenograms obtained would have been reduced by 30 per cent. Diabetes mellitus and spinal epidural abscess: clinical or surgical treatment?. Patients with recurrent MDD with multiple depressive episodes showed residual memory dysfunction even after 3 years of remission. A field trial was carried out with young cattle grazing molybdenum-rich pastures to test the efficacy of supplying copper salts in drinking water. Second, the water volume of the reservoir, which determines bacterial dilution and, consequently, the probability of contracting cholera by ingesting contaminated water.

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Lipid-containing mimetics of natural triggers of innate immunity as CTL-inducing influenza vaccines. To examine factors affecting cycling exercise performance in individuals with acquired brain injury. These studies demonstrate that extrahypothalamic effects upon adrenocortical secretion are neurally mediated, and that the integrity of neural pathways impinging upon the mediobasal hypothalamus from both the rostral and the caudal directions is essential to these effects. Moreover, we extended the SILAC fly strategy to study the dynamics of protein ubiquitination during the fly life span (from day 1 to day 30), by measuring the level of ubiquitin along with two major polyubiquitin chains (K48 and K63 linkages). However, further comparisons revealed that only one major protein antigen (band at an approximate molecular weight of 81,000) was represented in all the assayed human tumors while being absent from human placenta or kidney. Some factors influencing SMC proliferation as well as some aspects of SMC biology the knowledge of which is necessary for better understanding of some current hypotheses of atherosclerosis are considered. Characteristic curve patterns were identified for normal subjects and for patients with shunts with correlation to catheterization data.

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Degradation of carbofuran derivatives in restricted water environments: basic hydrolysis in AOT-based microemulsions. A multimodule curriculum of palliative care for medical students can significantly improve their knowledge on principles of clinical management and beliefs about ethical decision-making in palliative care. A band-tunable, multichannel amplifier for neural recording with AP/LFP separation and dual-threshold adaptive AP detector. In addition to the native anomalous signal from the haem iron, an NaI anion halide salt derivative and a complementary CsCl alkali-metal cation salt derivative were used. Shifts at candidate loci underlying adaptive responses and DNA regions that control their expression have now been linked to evolutionary responses to pollution, global warming and other changes. Leadership skills training in the education of psychiatrists should contain both practical experience with leadership and management roles and formal teaching sessions on leadership and management skills development. This review summarizes our emerging understanding of KIR-HLA diversity in human health and disease. The intranasal route also provides several practical advantages, such as greater acceptability to patients because of the noninvasive mode of delivery, the ability to take medication when severe nausea or vomiting is present, and a better adverse event profile.

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We included all 14,434 consecutive patients admitted for ST-segment elevation MI or non-ST-segment elevation MI at our center between 1985 and 2008. A competitive protein-binding assay for 25-hydroxycholecalciferol and 25-hydroxyergocalciferol in serum. This same duality obtains in the year 2000, albeit with the additional presence of a third, biomedical player whose activities are similarly structured by a common orientation, rather than by an exclusive commitment to a specific sub-domain. The protocol has not been tested for protein import activity but is optimized for chloroplast proteome yield and purity and minimal protein degradation. A rare disease of lungs, leiomyomatosis, is discussed in the article. The cytoplasts, similarly examined, appear to contain all cytoplasmic organelles and systems, including centrioles and microtubules. Thus, our findings provide support for ongoing efforts to expand TB diagnostic capacity. The aim of this study was to determine if protein metabolism was altered in small and large intestines by feeding pectin, a soluble fiber known to stimulate cecal production of short-chain fatty acids (SCFAs) and to have a trophic effect in these tissues. Our results may confer insight for the clinical development of an efficient antiangiogenic therapeutic manual and a timely chemoprevention to suppress tumor growth. The Chief Medical Officer of Health of each province/territory was sent a short survey asking whether there currently was a Public Health preschool vision screening program in place and if so, for specifics about the program.

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Development of a novel method for analyzing collagen O-glycosylations by hydrazide chemistry. The effect of ambient chloride concentration changes on branchial chloride-bicarbonate exchanges and hemolymph acid-base balance of crayfish. Similarly, elongator tRNA(Met) was translocated into the nucleus and formed granules during heat stress. The role of contaminant exposures regarding morbillivirus mortality is still unclear. To discriminate resistant and sensitive viruses, fifty percent inhibitory concentrations for the neuramidase inhibitors oseltamivir and zanamivir were determined in a neuraminidase inhibition assay. In this pilot study, osteoporosis leads to greater RRR, decreased masticatory performance and efficiency in edentulous subjects 6 months after denture insertion. smegmatis, respectively, with the lepromatous leprosy serum pool used as the antibody source.

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This increase was only due to an augmentation in the number of patients with alcoholic chronic pancreatitis. Biomedical informatics (BMI) is an umbrella scientific field that covers many domains, as defined several years ago by the International Medical Informatics Association and the American Medical Informatics Association, two leading players in the field. The study included 382 children, who in the years 2001 to 2010 were diagnosed with type 1 diabetes. Among the homeless, longer duration and more severe degree of homelessness lowered HRQoL, but few determinants were statistically significantly related to HRQoL. The arrays consisted of 2,464 bacterial artificial chromosome clones. There is an urgent need for better documentation of etiologic factors. (ABIS), Houghton Scale (HS), six-minute walk test (6MWT), and 10-metre walk test (10 MWT) were performed. Factor IX thrombogenicity: in vivo effects on coagulation activation and a case report of disseminated intravascular coagulation.

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The purified sophorolipids were characterized by ESI-MS and FT-IR. Descriptive analysis of the Emergency Department (ED) and surgical case records was performed. These chemical mediator families, termed resolvins and protectins, are potent stereoselective agonists that control the duration and magnitude of inflammation, joining the lipoxins as signals in resolution. An example of a small cell carcinoma metastatic to the thyroid is presented in this report. The effect of bilateral ablation of the amygdala on endocrine function in the rat. In summary, we report a comprehensive retinal cell-based proteomic approach for the identification of potential secreted retinal markers-induced in high glucose conditions. Mucocele-like tumor associated with ductal carcinoma in situ diagnosed as mucinous carcinoma by fine-needle aspiration cytology: report of a case. Ethnic discrimination prevalence and associations with health outcomes: data from a nationally representative cross-sectional survey of secondary school students in New Zealand. When the Farr test was repeated using larger concentrations of antigen the ABC measurements increased several-fold. There remained a low degree of predicted cross-resistance to other widely used PIs.

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Immediate production of a tubular dense collagen construct with bioinspired mechanical properties. However, the size of such effects is modulated by vascular origin such as intravascular, extravascular, macro and microvascular, venular and capillary, the relative contributions of which depend not only on the spatial resolution of the measurements, but also on stimulus duration, on magnetic field strength and on whether spin echo (SE) or gradient echo (GRE) detection is used. Experience with the use of close-relative allograft for the management of extensive thermal injury in local national casualties during Operation Iraqi Freedom. Meanwhile treatment protocols have been developed to achieve successful transplantation across antibody barriers. A PubMed search (using English language as a filter) was performed to identify factors affecting PSMs and their management.

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Fifty-seven children with POTS were designated as the POTS group. Individual assessment of platelet function is advised when administering these drugs prior to surgery, particularly in the presence of other risk factors for bleeding. Numerous immunomodulation molecules or derivatives are now available for clinical investigations. The relationship between the radiobiological effect and the HCP topography in the seed was established: zones of the root and stem meristema proved to be most sensitive targets. These quantitative thermodynamic results provide a preliminary indication on the molecular mechanism of binding of the multifunctional protein YB-1 to nucleic acids to regulate its biological function. In vitro it has been shown that pancreatic stellate cells are transformed into proliferating myofibroblasts mainly by transforming growth factor beta (TGF-beta) and platelet-derived growth factor (PDGF). Because the orexigenic peptide, ghrelin, is active through systemic routes and activates hypothalamic neuropeptide systems known to be refractory in anorectic tumor-bearing (TB) rats, we investigated whether it would prevent the development of cancer anorexia when infused continuously intravenously. The most important experimental data about changes in CFUs, BFUe and CFUe after acute or chronic irradiation, anaemia, hypoxia, hypertransfusion or direct erythropoietic stimulation can be reproduced within the model. Based upon nationwide workshops and agreement on clinical guidelines for perioperative care a questionnaire was sent to all surgical departments which perform the five procedures. Glia, specifically astrocytes and microglia, have been shown to contribute directly to behaviors predictive of the abuse liability of these drugs.

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Proper and individualized treatment for patients with a low ABI may improve long-term functional outcome following acute cerebral infarction. Damages to the mitochondria and to the lamellar bodies and swelling of the endothelial and alveolar cells were major observations following cardiopulmonary bypass lasting more than 60 minutes. The experimental data were analyzed according to the Lotka-Volterra model for prey-predator relationships and by the Monod model for saturation kinetics. Rather, there appears to be a substantial overlap between the field of origin of fibres of the anterior commissure and those of the largest cerebral commissure, the corpus callosum. To examine the epidemiology and timing of penile fracture, patterns of urethral evaluation, and risk factors for concomitant urethral injury. Influence of quercetin on the pharmacokinetics of ranolazine in rats and in vitro models. Adjunctive use of rifampin for the treatment of Staphylococcus aureus infections: a systematic review of the literature. The role of EEG oscillations in human information processing has been intensively investigated. Questions such as the law that was accorded by National Board Examinations for Dentist in Japan, the qualification of the examinee, the organization of the committee, the implementation of the exam, testing items development and the eligibility criteria were introduced in details in this article.

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Cardiometabolic syndrome (CMS), a cluster of metabolic abnormalities that increases the risk of cardiovascular disease (CVD) and type 2 diabetes, affects over one-third of American adults and accounts for billions of dollars in health care costs annually. Infants with lower GA are at greatest risk of postnatal CMV infection, especially when fed with fresh breast milk from their non-native Dutch mother. Retrovirus-containing conditioned medium from packaging cells is used to transduce target cells. Optimization of municipal solid waste collection and transportation routes. This flonase dosage instructions article highlights the important aspects in choosing this surgical approach and managing ventral posterior fossa meningiomas through the EEA. Using reversible inactivation in rats, we demonstrate that vmPFC activity is also required for inhibition of unreinforced actions extinguished during learning of a cued appetitive task and that behavioral disinhibition following vmPFC inactivation depends on dopamine signaling in nucleus accumbens shell (NAcS). Those genes that are highly expressed during the first year of postnatal life may influence and orchestrate the early development of cortical neural circuitry while genes portraying a pattern of increasing expression with age may indicate a role in DLPFC maturation and attainment of adult levels of cognitive function. Among subjects with severe asthma, we identified eosinophilic and noneosinophilic phenotypes using both bronchial biopsies and sputum cell counts. Vesicles and organogels from foldamers: a solvent-modulated self-assembling process. An immunohistochemical analysis of the tissue revealed the presence of infectious bacteria that were characteristic of the genus Helicobacter sp.

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To assess the results of posterior neodymium:YAG (Nd:YAG) laser capsulotomy in patients with late postoperative capsular block syndrome (CBS) with decreased vision because of posterior capsule opacification (PCO). Checkpoint kinase 1 (Chk1, CHEK1) is a Ser/Thr protein kinase that plays a key role in mediating the cellular response to DNA-damage. In particular, I consider the following attributes of prey: group size and dilution of direct predation risk, the degree of foraging specialization, body mass, and the degree to which direct predation is additive vs. This paper highlights the bio-chemical and pharmacological differences between the LMWH preparations that may result in different clinical outcomes, and also reviews the implications and challenges physicians face when generic versions of the original/innovator agents are approved for clinical use. Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. These interactions may be instrumental in generating the complex rhythmic motor patterns of the mandibles and gut muscles during locust feeding or ecdysis-related air swallowing.

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Data of 32 patients with thoracic fractures accompanied with sternum fracture were reviewed. An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation. Adopting a practise Development (PD) framework provided a clear structure and direction for the NGDP. Further analysis on the intensity of recreational PA demonstrated different dose-response associations between moderate- and vigorous-intensity recreational PA and breast cancer risk. We interpreted this to confirm that the length of translocated chromosome segments has some influence on the proportion of unbalanced gametes in the ejaculate, presumably reflecting the frequency with which adjacent-1 and adjacent-1 segregations and 3-1 misdivisions occur. No author has a financial or proprietary interest in any material or method mentioned. All four studies had the same study protocol, recruitment (cluster, school-based sampling), questionnaire (WHO respiratory health questionnaire) and the same principal investigator The surveys included 1130 children in 1993, 1421 children in 2002, 1661 children in 2007 and 1698 in 2014. A proper use of these new concepts leads to the conclusion that despite the different principles underlying their construction, they provide two equivalent excited states topological analyses.

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The major concept of conjunctival surgery for dry eye is to smoothen the surface in order (1) to reduce blink-associated microtrauma, (2) to reconstruct the tear meniscus and conjunctival fornix and their respective functions as reservoirs for tears, and (3) to reduce conjunctival inflammation by the removal of abnormal fibrous tissue combined with the use of mitomycin C and/or amniotic membrane. Groups of mice underwent a buried food-pellet test to gauge olfactory function and then were nasally irrigated with 1 of 3 divalent cationic compounds. This study supports the relationship between DUP and outcome beyond the early stages of illness. Finally, we compared the efficiency of each method in sex determination. The conserved, fusion-active HA2 glycopolypeptide (HA2) subunit of influenza A hemagglutinin comprises four distinct antigenic sites. To evaluate the use of ultrasound (US), in relation to electrophysiological testing, for this purpose. The authors evaluated 8-OHdG in drained dialysate by enzyme immunoassay to investigate the association between 8-OHdG and solute transport rate estimated by peritoneal equilibration test and matrix metalloproteinase-2 (MMP-2) level in what is the generic version of claritin 45 samples from 28 PD patients.

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The methods of genetic engineering and protein design are now widely used to study the catalytic mechanism and to improve properties of the enzyme. We examined the relationship of the pretreatment serum level to IHC findings for CgA and NSE in prostate cancer patients to clinicopathological parameters, and prognosis. The essential amino-acid composition was compared with the FAO pattern of amino-acid requirements and to the protein of milk and eggs. To test our approach, we assumed that the second distribution was also a Poisson distribution. Corticosteroid administration and localized leukocyte mobilization in man. Non-tuberculous mycobacterial infections are rare in immunocompetent subjects. It also highlights how, for these less tangible factors, it is possible to identify more concrete stressors and outcomes which are amenable to management and monitoring. A history of irradiation, disease recurrence, secondary TEP, and high-volume neck disease were predictive of multiple injections. This conceptual framework is extending the original perspective of phenomenology to issues of modern technology and science.

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The authors report a case of intraparenchymal germinoma pathologically diagnosed using navigation-guided endoscopic biopsy. Newer and more sophisticated radiofrequency devices are being brought to the market and presented here are the Venus Freeze and Venus Legacy. An investigation of the efficacy of invasive-noninvasive sequential mechanical ventilation in senile patients with severe community-acquired pneumonia. A high capacity F-actin affinity matrix is constructed by binding fluorescyl-actin to rabbit anti-fluorescein IgG that is covalently bound to Sepharose 4B. A comparison of oral dexamethasone with oral prednisone in pediatric asthma exacerbations treated in the emergency department.

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Degenerating cells were found at the earliest stage examined in both regions (stage 29 in the brachial region and stage 28 in the lumbar region). By this method, leptospires were detected down to a concentration of 10(2)-10(4) organisms/ml. Research and education on lesbian health has increased substantially in quantity and quality in the past 40 years, but little of this work has been produced by nursing scholars. Cervical spondylotic myelopathy (CSM) refers to impaired function of the spinal cord caused by degenerative changes of the cervical spine resulting in spinal cord compression. Transcriptome analysis of Rhodococcus jostii RHA1 during growth in sterilized soil was performed. Decrease in Prostate Cancer Testing Following the US Preventive Services Task Force (USPSTF) Recommendations.

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