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Zepnap (Lorazepam)

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Zepnap, an antianxiety agent, has the chemical formula, 7-chloro-5-(o-chlorophenyl)-1,3- dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one. It is a nearly white powder almost insoluble in water. Each Zepnap tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of lorazepam. The inactive ingredients present are lactose monohydrate, magnesium stearate, microcrystalline cellulose, and polacrilin potassium.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

Similar Products:
Dilantin, Elocon, Danocrine, Diamox, Zyrtec, Buspar, Antabuse

Also known as: Lorazepam


Zepnap belongs to a class of medications called benzodiazepines. These medications work by boosting the activity of gamma-aminobutyric acid (GABA) within your body.

GABA is a neurotransmitter that transmits messages between cells in different parts of your body. Increasing GABA in the body results in a tranquilizing effect that reduces feelings of stress and anxiety.

How long does it take to work?

Benzodiazepines such as Zepnap are categorized based on how fast they work. Zepnap is classified as having a rapid to intermediate onset (start) of action. It begins to work right away after it’s taken, but its peak effect occurs within 1 to 1.5 hours.


The Zepnap dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Zepnap to treat
  • your age
  • the form of Zepnap you take
  • other medical conditions you may have
Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Drug forms and strengths

  • Tablet: 0.5 mg, 1 mg, 2 mg
  • Solution for injection (IV): 2 mg per mL, 4 mg per mL

General dosage information

The usual oral dosage for Zepnap tablets is 2 to 6 mg daily. This dosage amount is usually divided and taken two or three times daily.

Dosage for anxiety

Typical dosage: 1 to 3 mg taken two or three times daily.

Dosage for insomnia due to anxiety or stress

Typical dosage: 2 to 4 mg at bedtime.

Dosage for IV Zepnap

  • Intravenous (IV) Zepnap will be given by your doctor or nurse. Your doctor will determine the best dosage for your condition.

Special dosage considerations

Older adults and people with certain physical conditions may need to start with a lower dosage. This might be 1 to 2 mg, taken two or three times daily for anxiety or once at bedtime for insomnia.

What if I miss a dose?

If you miss a dose, take it as soon as you can. However, if it’s just a few hours until your next dose, skip the missed dose and take the next one on schedule.

Never try to catch up by taking two doses at a time. This can cause dangerous side effects.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Zepnap can be fatal. Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, fainting, or coma.


Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Zepnap is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Zepnap are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Zepnap can interact with several other medications. It can also interact with certain supplements and foods.

Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.

Zepnap and other medications

Below is a list of medications that can interact with Zepnap. This list doesn’t contain all drugs that may interact with Zepnap.

Before taking Zepnap, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.


Taking opioids with Zepnap can cause dangerous side effects. These include excessive drowsiness, breathing problems, respiratory failure, and coma.

Examples of these drugs include:

  • morphine (Astramorph PF, Kadian, MS Contin, and others)
  • oxycodone (Percocet, Roxicet, Oxycontin, and others)
  • hydrocodone (Zohydro ER, Hysingla ER)
  • methadone (Dolophine, Methadose)
  • fentanyl (Abstral, Duragesic, and others)
Opioids should only be used with Zepnap when there are no other treatment alternatives.

Sedative drugs

Taking sedative drugs with Zepnap can cause excessive drowsiness and breathing problems. Examples of sedative drugs include:

  • anticonvulsant medications such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), phenytoin (Dilantin, Phenytek), and topiramate (Qudexy XR, Topamax, Trokendi XR)
  • antihistamines such as diphenhydramine (Benadryl), cetirizine (Zyrtec), chlorpheniramine (Chlor-Trimeton and others), and doxylamine (Unisom and others) — also found in over-the-counter and combination products
  • antipsychotic drugs such as clozapine (Clozaril, Fazaclo ODT), haloperidol (Haldol), quetiapine (Seroquel), and risperidone (Risperdal)
  • anxiety drugs such as buspirone (Buspar)
  • barbiturates such as phenobarbital
  • other benzodiazepines such as alprazolam (Xanax), clonazepam (Klonopin), diazepam (Valium), and midazolam

Taking Zepnap with probenecid, a drug that can be used to treat gout, can increase the levels of Zepnap in your body. This can increase your risk of Zepnap side effects. For people who take probenecid and Zepnap together, the Zepnap dosage needs to be reduced by half.

Valproic acid

Taking Zepnap with valproic acid (Depakene, Depakote), a drug used to treat seizures and other conditions, can increase the levels of Zepnap in your body. This can increase your risk of Zepnap side effects.

For people who take valproic acid and Zepnap together, the Zepnap dosage needs to be reduced by half.

Zepnap and Zoloft

Zoloft (sertraline) can make some people feel tired or drowsy. Zepnap can also cause drowsiness. Taking these medications together may cause you to feel even more tired or drowsy.

Zepnap and Ambien

Zepnap and Ambien (zolpidem) shouldn’t be taken together. Both medications are used to help promote sleep. If taken together, they can cause excessive sleepiness and sedation.

Taking this combination of medications can also increase the risk of odd behaviors such as sleep-driving (trying to drive while asleep).

Zepnap and Tylenol

There are no known interactions between Zepnap and Tylenol (acetaminophen).

Zepnap and herbs and supplements

Taking Zepnap with herbs or supplements that have sedative effects can cause excessive drowsiness and breathing problems. Examples of sedative herbs and supplements that can cause these effects include:

  • chamomile
  • kava
  • lavender
  • melatonin
  • valerian
Zepnap and marijuana

Marijuana shouldn’t be used with Zepnap. Using marijuana with Zepnap can cause excessive drowsiness or sedation.

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Harnessing recombination to speed adaptive evolution in Escherichia coli. Clinical improvement has been good, but objective reversal of right ventricular dysfunction has been difficult to document. Here, participants listened to and repeated back foreign phonological forms (Korean words) and new native-language word forms (Finnish pseudowords) on two days. Our goals were to detect the space-time distribution pattern of malaria and to determine significant environmental variables contributing to malaria incidence in Yongcheng from 2006 to 2010, thus providing scientific basis for further optimizing current malaria surveillance and control programs. Disturbances of arterial blood supply to the spinal cord and brain stem caused by spondylosis, disc protrusions and root-sleeve fibrosis. The presence of either the mitogen-activated protein kinase (MAPK) inhibitor (PD98059), or PI-3K inhibitor (LY294002), reduced the effect of adiponectin in a dose-dependent manner. Changes in concentrations of insulin, growth hormone and metabolites in plasma with spontaneous feeding in lactating dairy cows. The aim was to compare the impact of permanent fixation (PF) with no fixation (NF)/nonpermanent fixation (NPF) of mesh on chronic pain after TEP repair for primary inguinal hernia. This case of Meyerson phenomenon revealing melanoma shows that the melanocytic lesions targeted by MP are not necessarily benign.

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We compared two DNA extraction methods (a semiautomated method using a Maxwell kit and a modified Boom method) and three amplification procedures (a single-step PCR, a nested PCR, and a real-time quantitative PCR) on 74 surgical tissue specimens from patients with clinically suspected Buruli ulcer. Statins treatment may significantly improve the endothelial function of CHD patients. Rubella antibody determination from heparinised finger-tip blood by single radial haemolysis and enzyme immunoassay. Current knowledge of the anatomy of the lymphatic system does not match or explain some of the unexpected clinical and lymphoscintigraphic findings seen in head and neck cancer patients. The results show that water confined between two parallel hydrophobic plates is in a thermodynamic metastable state. The emergency department (ED) serves as the entry point into the U.S. The effect of phenglutarimid (aturbane) on salivary secretion in man. Both temperature variation and chemical modification are believed to affect the relative importance of polymer-polymer and polymer-subphase interactions.

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This video protocol demonstrates an effective technique to knockdown a particular gene in an insect and conduct a novel bioassay to measure excretion rate. Matrix metalloproteinases (MMPs) are a family of extracellular endopeptidases responsible for the degradation and remodelling of extracellular matrix, they are known to be involved in the progression and invasiveness of many types of tumour. Most of them, including chemokines and extracellular matrix proteins, have attractant properties on thymocytes. Although previous studies have indicated that cyclophilin B ( glucophage xr 500 mg para que sirve CypB) plays a role in ER stress, there is currently no direct information supporting the mechanism of CypB involvement under hypoxic conditions. The mean FECs were between 583.3 and 4441.7 in the young group and between 418.2 and 2181.8 in the adult group.

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