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Zelor (Lorazepam)

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Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. It is used to treat anxiety disorders, trouble sleeping, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy induced nausea and vomiting, as well as for surgery to interfere with memory formation and to sedate those who are being mechanically ventilated. While it can be used for severe agitation, midazolam is usually preferred. It is also used, along with other treatments, for acute coronary syndrome due to cocaine use. It can be given by mouth or as an injection into a muscle or vein. When given by injection onset of effects is between one and thirty minutes and effects last for up to a day.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

Similar Products:
Pyridium, Ambien, Rebetol, Zudena, Zanaflex, Albenza, Skelaxin, Valium, Imitrex

Also known as: Lorazepam


Zelor belongs to a class of medications called benzodiazepines. These medications work by boosting the activity of gamma-aminobutyric acid (GABA) within your body.

GABA is a neurotransmitter that transmits messages between cells in different parts of your body. Increasing GABA in the body results in a tranquilizing effect that reduces feelings of stress and anxiety.

How long does it take to work?

Benzodiazepines such as Zelor are categorized based on how fast they work. Zelor is classified as having a rapid to intermediate onset (start) of action. It begins to work right away after it’s taken, but its peak effect occurs within 1 to 1.5 hours.


Take Zelor exactly as it was prescribed for you. Follow all directions on your prescription label. Never use Zelor in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in treating your symptoms.

Lorazepam may be habit-forming. Never share Zelor with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Misuse of habit-forming medicine can cause addiction, overdose, or death. Selling or giving away Zelor is against the law. Zelor should be used for only a short time. Do not take this medicine for longer than your doctor recommends.

Do not stop using Zelor suddenly or you could have unpleasant withdrawal symptoms, including a seizure (convulsions). Ask your doctor how to safely stop using this medicine. Call your doctor if this medicine seems to stop working as well in treating your anxiety symptoms.


In cases of a suspected Zelor overdose, it is important to establish whether the patient is a regular user of Zelor or other benzodiazepines, since regular use causes tolerance to develop. Also, one must ascertain whether other substances were also ingested.

Signs of overdose range through mental confusion, dysarthria, paradoxical reactions, drowsiness, hypotonia, ataxia, hypotension, hypnotic state, coma, cardiovascular depression, respiratory depression, and death.

Early management of alert patients includes emetics, gastric lavage, and activated charcoal. Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil.

Patients are ideally nursed in a kind, nonfrustrating environment, since, when given or taken in high doses, benzodiazepines are more likely to cause paradoxical reactions. If shown sympathy, even quite crudely feigned, patients may respond solicitously, but they may respond with disproportionate aggression to frustrating cues. Opportunistic counseling has limited value here, as the patient is unlikely to recall this later, owing to drug-induced anterograde amnesia.


Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Zelor is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Zelor are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


The additive central-nervous-system effects of other drugs, such as phenothiazines, narcotic analgesics, barbiturates, antidepressants, scopolamine, and monoamine-oxidase inhibitors, should be borne in mind when these other drugs are used concomitantly with or during the period of recovery from Zelor Injection.

Extreme caution must be used when administering Zelor Injection to elderly patients, very ill patients, or to patients with limited pulmonary reserve because of the possibility that hypoventilation and/or hypoxic cardiac arrest may occur. Resuscitative equipment for ventilatory support should be readily available.

When Zelor injection is used IV as the premedicant prior to regional or local anesthesia, the possibility of excessive sleepiness or drowsiness may interfere with patient cooperation in determining levels of anesthesia. This is most likely to occur when greater than 0.05 mg/kg is given and when narcotic analgesics are used concomitantly with the recommended dose.

As with all benzodiazepines, paradoxical reactions may occur in rare instances and in an unpredictable fashion. In these instances, further use of the drug in these patients should be considered with caution.

There have been reports of possible propylene glycol toxicity (e.g., lactic acidosis, hyperosmolality, hypotension) and possible polyethylene glycol toxicity (e.g., acute tubular necrosis) during administration of Zelor Injection at higher than recommended doses. Symptoms may be more likely to develop in patients with renal impairment.

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Monte Carlo simulation for a decision tree model incorporating the following chance events: development of GBS sepsis during the second 24 hours of life, development of GBS sepsis between 48 hours and 7 days of life, prompt versus delayed treatment for sepsis, neonatal mortality and long-term health sequelae. The comparison of single catechols (dopamine) with multiple catechols on hyperbranched polyglycerols (hPG) at various pH and dwell times allowed us to further increase our understanding. Optical coherence tomography examinations were performed by using a modified commercial OCT system comprising a Ti:sapphire femtosecond laser to support an enhanced resolution of 3 microm axial x 10 microm lateral. Physicians should interpret these burdens in the individual context and consider them in their treatment planning. Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin. Studies examining the link between stressful events and coping with HIV have relied on a between-persons approach focusing on how individuals differ on some characteristics. First-in-man study of simvastatin-eluting stent in de novo coronary lesions: the SIMVASTENT study.

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Evaluating the efficacy of acupuncture in defined aspects of stroke recovery: a randomised, placebo controlled single blind study. We evaluated, along with phagocytosis, the production of reactive oxygen species (ROS), matrix metalloproteinase-8 (MMP-8), and interleukin-1beta by neutrophils in response to non-periodontopathic Streptococcus sanguinis and periodontopathic bacteria Fusobacterium nucleatum and Treponema denticola, in the absence or presence of antibodies. Tyrosine contributions to the structure-function relationship in the fructose-1, 6-biphospate aldolase from C. Respiratory control and the basis of light-induced inhibition of respiration in chromatophores from Rhodopseudomonas capsulata. The treatment was well tolerated and seemed to confer a significant prolongation of survival, comparing favourably with previous reports of chemotherapy with or without radiotherapy. However, collection of several urine samples provides a method to achieve the same visualization of gonadotropin patterns in patients using a convenient and generally applicable technique based on analysis of the highly stable hLHbetacf for monitoring LH and hCGbetacf for monitoring pituitary hCG. 2-Hy-droxy-N,N,N-trimethyl-3-tetra-decyl-oxypropan-1-aminium bromide. We evaluated patient satisfaction and its correlates in a consecutive sample of patients undergoing external beam radiation therapy. Such multilevel evolution leads to long-term information integration. Impact of multiparametric endorectal coil prostate magnetic resonance imaging on disease reclassification among active surveillance candidates: a prospective cohort study.

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A Statistical Analysis of a Traffic-Light Food Rating System to Promote Healthy Nutrition and Body Weight. To elucidate its effects on the skin, we investigated the transcriptional profiles of side effects of actos 15 mg kaempferol-treated HaCaT cells using cDNA microarray analysis and identified 147 transcripts that exhibited significant changes in expression. The HFE redesign concepts incorporated into Drawer 2 (consisting of visibility, grouping, and organization) produced successful, low-cost, and generalizable modifications that can improve patient care. These defects were confirmed in vivo, resulting in decreased replication in Ae. Resistance by physicians, medical researchers, medical educators, and medical students to pharmaceutical industry influence in medicine is often based on the notion that physicians (guided by the ethics of their profession) and the industry (guided by profit) are in conflict. Early diagnosis and aggressive medical and surgical treatment might have saved the eyes.

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Carbodiimide fixation for electron microscopy and immunoelectron cytochemistry. Increased expression of eEF1A2 occurs during the development of breast, ovarian, and lung cancer. Also, the ability of PAR(2) agonists to enhance the effects induced by immune mediators during infection or inflammation is still poorly investigated. In these situations, the pre-emptive activation of survival signaling mechanisms would confer a prophylactic cardioprotection during the following ischemic stress. Results demonstrating the feasibility of quantifying PG in OA patients and comparison with that in healthy subjects are also presented. This study was conducted to investigate effects of coinfection of Porphyromonas gingivalis (P. LVM measured by 3D echocardiography is highly accurate compared to LVM measured by MRI.

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Data on unit-hours, call volume, and patient transports also were collected. Development of hydroxytryptophan decarboxylase activity in the pineal gland, cerebral hemispheres, and cerebellum of the chick embryo and young chick. D-Camphor-derived triazolium salts for catalytic intramolecular crossed aldehyde-ketone benzoin reactions. Delivery of PILs containing a second reporter gene (the pSV40 beta-galactosidase transgene) transplacentally by the same procedure was also successful. Males presented at a younger age while females presented at all sustiva 600 mg oral tablet ages with a somewhat similar incidence. The authors of the study recommend that gastrostomies should be considered for patients requiring long term post operative enteral nutritional support in patients of head and neck cancers.

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