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Tofranil

Tofranil, synthetic drug used in the treatment of depression and enuresis (bed-wetting). Introduced into medicine in the late 1950s, Tofranil was the first tricyclic antidepressant, a class named for its three-ring molecular structure.

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Alzoset, Anxitab, Anxofit, Depforte, Depik, Depof, Depsodep, Depsol, Depsolam, Depsonil, Diamin, Diazariv, Estidep, Imidiaz, Imilor, Iminza, Imipam, Imipra, Imipramine, Imodep, Impramine, Impranit, Imprim, Imprin, Karthin, Lastinem, Libomin, Normadep, Prazep, Talendep, Toframine, Trydep, Ultradep

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Also known as: Imipramine

Description

Generic Tofranil is used to treat depression. Generic Tofranil is also used on a short-term basis, along with behavioral therapies, to treat bed-wetting in children aged 6 and older. Sometimes Generic Tofranil is prescribed to treat bulimia, attention deficit disorder in children, obsessive-compulsive disorder and panic disorder. Generic Tofranil is a member of the family of drugs called tricyclic antidepressants. Tofranil is also known as Imipramine, Antideprin, Deprenil, Deprimin, Deprinol, Depsonil, Dynaprin, Eupramin, Imipramil, Irmin, Janimine, Melipramin, Surplix, Antidep, Apo-Imipramine, Chrytemin, Daypress, Depsol, Ethipramine, Fronil, Imidol, Imimine, Imine, Imiprex, Imiprin, Impril, Medipramine, Melipramine, Mipralin, Novopramine, Primonil, Pryleugan, Sermonil, Sipramine, Talpramin, Tofnil, Tofranil-PM, Venefon. Generic name of Generic Tofranil is Imipramine hydrochloride. Brand names of Generic Tofranil are Tofranil, Tofranil-PM.

Dosage

Take Generic Tofranil orally. Take Generic Tofranil with or without food. For adults The usual starting dose is 75 mg a day. The maximum daily dose is 200 mg. For children Total daily dosages for children should not exceed 2.5 mg for each 2.2 pounds of the child's weight. Doses usually begin at 25 mg per day. This amount should be taken an hour before bedtime. If needed, this dose may be increased after 1 week to 50 mg (ages 6 through 11) or 75 mg (ages 12 and up), taken in one dose at bedtime or divided into 2 doses, 1 taken at mid-afternoon and 1 at bedtime. Aged people The usual dosage should start with 25 to 50 mg per day. The dose may be increased as necessary, but effective dosages usually do not exceed 100 mg a day. If you want to achieve most effective results do not stop taking Generic Tofranil suddenly.

Overdose

If you overdose Generic Tofranil and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Tofranil overdosage: agitation, bluish skin, convulsions, difficulty breathing, dilated pupils, drowsiness, heart failure, high fever, involuntary writhing or jerky movements, irregular or rapid heartbeat, lack of coordination, low blood pressure, overactive reflexes, restlessness, rigid muscles, shock, stupor, sweating, vomiting.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Tofranil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Tofranil if you are allergic to Generic Tofranil components. Be very careful with Generic Tofranil if you are pregnant, planning to become pregnant, or are breast-feeding. Do not take Generic Tofranil if you are recovering from a recent heart attack or take MAO inhibitors, such as the antidepressants Nardil and Parnate. Be very careful with Generic Tofranil if you have diabetes, hypoglycemia, a history of mental disorders. Be very careful with Generic Tofranil if you are taking albuterol (Proventil, Ventolin), antidepressants that act on serotonin, including Prozac, Paxil and Zoloft, antipsychotic drugs such as Mellaril and chlorpromazine, barbiturates such as Nembutal and Seconal, blood pressure medications such as Catapres, Carbamazepine (Tegretol), cimetidine (Tagamet), decongestants such as Sudafed, drugs that control spasms, such as Cogentin, Epinephrine (EpiPen), Flecainide (Tambocor), Guanethidine, Methylphenidate (Ritalin), Norepinephrine, other antidepressants such as Elavil and Pamelor, Phenytoin (Dilantin), Propafenone (Rythmol), Quinidine, thyroid medications such as Synthroid, tranquilizers and sleep aids such as Halcion, Xanax, and Valium. Avoid alcohol. Do not participate in any activities that require full alertness if you are unsure about your ability. Try to stay out of the sun as much as possible. It can be dangerous to stop Generic Tofranil taking suddenly.

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At four months, four subpopulations were identified depending on the presence or not of exercise-induced pain. Gene therapy for ocular diseases meditated by ultrasound and microbubbles (Review). We examined 706 breast cancer patients and 1412 age- and menopausal status-matched noncancer controls. The development of the hypothalamo-hypophysial portal system in human fetus. MR acoustic radiation force imaging (ARFI) is an elegant adjunct to MR-guided high intensity focused ultrasound for treatment planning and optimization, permitting in situ assessment of the focusing and targeting quality. Characterization of the complex molecular signaling networks between the various components of host-pathogen interactions, highlights the difficulty in identifying a single driving force responsible for sepsis. Mucosal irritation present in certain of the subjects at the start of the study was eliminated in almost all cases with the continuing use of the assigned adhesive during the six-month observation period.

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Community pharmacists seek information regarding legislative changes when such changes come into force to a greater degree than when the legislation is drafted, consulted upon or enacted. Attempt at reconstitution of the karyotype of the common ancestor. Working conditions of the workers on specialized potato-raising farms. We investigated the sensitivity of urine-based methods (Xpert MTB/RIF, LAM strip test and LAM ELISA) in such patients. Samples were centrifuged and the cell-free supernatant frozen at -80 degrees C. This review is focused on the development of chemokine receptor antagonists for anti-asthma, which will promote the compound designations.

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Participants viewed scenes that were either novel, repeated, or manipulated (i.e., a change was introduced in one region of the scene). A Diet and Exercise Intervention during Chemotherapy for Breast Cancer. The folding pathway of T4 lysozyme: an on-pathway hidden folding intermediate. Processing of compound-word characters in reading Chinese: an eye-movement-contingent display change study. See Instructions for Authors for a complete description of levels of evidence. This study confirms that quitters place risks to their personal health as the highest factors influencing their decision to quit, and health professionals should be aware of this when designing smoking-cessation initiatives. Angiotensin II is an important pro inflammation factor in the cardiovascular system.

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These changes are incorporated into an equivalent circuit model for cells and tissue with a variable EP-based resistance, providing a potential method to estimate conductivity as a function of electric field and pulse length for other tissues. Despite high contents of bioactive factors, colostrum did not significantly improve intestinal absorption, body composition or functional tests compared with the control. A prospective multicenter study of imidafenacin 0.1 mg twice daily for patients with OAB and nocturia was conducted. Effect of exogenous melatonin on X-ray induced cellular toxicity in lymphatic tissue of Indian tropical male squirrel, Funambulus pennanti. From our database, we selected 523 EOS records suitable for 3D modelling representing age groups between two and 16 years in which no relevant deviation influencing lower-limb biomechanics could be observed (the majority of the examined population had mild scoliosis). In free solutions, this analog inhibited acetylation of the various nuclear histones to a similar extent. Combinatorial pulsed laser deposition of Fe, Cr, Mn, and Ni-substituted SrTiO3 films on Si substrates.

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Social support and adjustment: predictive benefits of social climate indices. At the crossroads between tension-type headache and fibromyalgia. The proposed definition of biliary fistula provides effective recognition of those that are clinically relevant with a reduction of the risk of unrecognized collections and minimal postoperative morbidity. After treatment, the therapeutic effect was assessed by measuring the size of trauma. Hyperthermia and severe rhabdomyolysis from synthetic cannabinoids. Transgene-dependent incompatibility induced by introduction of the SK2:ZPT2-10 chimeric gene in petunia. However, RNA dependant virus replication has a high mutation rate. The reaction of canine prostatic epithelium was studied ultrastructurally and histochemically (acid phosphatase, zinc) in mature Beagle-dogs 15 minutes after intravenous application of pilocarpine (1 mg/kg body weight).

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The phagocyte NADPH oxidase catalyzes the NADPH-dependent reduction of molecular oxygen to generate superoxide O2-., which can dismute to generate ROS species. Ackerman in 1947: strictly lokalized tumor, no metastatic spread, yet strong tendency to recidivity. Protegrins are beta-hairpin peptides with high activity against a wide variety of microbial species, but in their native state are toxic to human cells. Their antimicrobial, antiviral, antitumor, antioxidative, cardioprotective (antihypertensive, antiatherosclerotic and anticoagulant), immunomodulatory, analgesic, anxiolytic anti-diabetic, appetite suppressing and neuroprotective activities have attracted the attention of the pharmaceutical industry, which attempts to design them for use in the treatment or prevention of various diseases. This paper reports the results for linear growth of 489 children who were followed-up for the first 12 months of their lives. Non-toxic doses of poly-APS also potently reduced NSCLC cell-cell adhesion in suspension cultures. miR-15a may have a potential application value in breast carcinoma biotherapy. Residual pivot shift after ACL reconstruction is a crucial factor related to poor clinical outcome. Only four annetocin-IR cells were seen in the cerebral ganglion.

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A 38-year-old woman with a moderate Class III alveolar ridge defect received periodontal plastic surgery treatment using a combined onlay-interpositional graft procedure and a subepithelial connective tissue graft. The concentrations of dehydroepiandrosterone and uric acid remained stable across all of the days, as did the melatonin concentrations between workdays 5 and 7. Recurrence of an injury already reported in the trial period was not included to avoid recording the same injury more than once. Experiment 1 showed that corrections reduced misinformation reliance in both the explicit and implied conditions, but the correction was much less effective following implied misinformation. Television viewing and abdominal obesity in young adults: is the association mediated by food and beverage consumption during viewing time or reduced leisure-time physical activity?. Multiple augmentative procedures may be indicated for the esthetic reconstruction of edentulous alveolar ridge deformities due to unpredictable shrinkage of augmented tissues. The objective of this study is to describe high-resolution manometry (HRM) topography as it relates to the post-fundoplication anatomy. The appearance of fractional spatial frequency percepts draws into question the notion that frequency-doubling is solely generated by spatially non-linear Y-type magnocellular ganglion cells. Comparison of hyperfractionation and conventional fractionation radiotherapy with concurrent docetaxel, cisplatin and 5-fluorouracil (TPF) chemotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN).

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RNA interference induced by ingestion of dsRNA from the Pns10 gene of RRSV strongly inhibited such viroplasm formation, preventing efficient virus infection and spread in its insect vectors. Tyrosine kinase substrate with five SH3 domains (Tks5, also known as SH3PXD2A) and cortactin are required for the formation of invadopodia, actin-based protrusions of tumour cells with associated proteolytic activity implicated in tumour invasion. Both PGI2 and PGE2 had a similar effect on intrarenal hemodynamics, i.e., caused a progressively greater proportional vasodilation from superficial to deep cortex. We investigated the potential of dual-energy X-ray absorptiometry (DXA) for measuring total-body SM in pediatric subjects. This has led to renewed interest in the therapeutic potential of natural anti-infective agents such as host defense peptides (HDPs). Low scores in extraversion contribute to explain the presence of agoraphobia in panic disorder.

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