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Rebetol (Ribavirin)
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Rebetol

Rebetol is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses. Rebetol is incorporated into viral RNA, thereby inhibiting viral RNA synthesis, inducing viral genome mutations, and inhibiting normal viral replication.

Other names for this medication:
Copegus, Ribavin, Ribavirin, Virazide, Virazole

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Also known as: Ribavirin

Description

Rebetol is an anti-viral drug indicated for severe RSV infection, hepatitis C infection and other viral infections. Rebetol is manufactured by Merck Sharp and Dome (a subsidary of Merck and Co., Inc.). The active ingredient, Ribavirin is a professional grade drug, which when metabolized resembles purine RNA nucleotides. In this form it interferes with RNA metabolism required for replicationRebetol. Ribavirin helps the immune system fight the virus and makes it harder for the virus to reproduce within the body. Rebetol is prescribed in combination with other medications such as sofusbuvir and peginterferon alfa 2a/2b for preventing hepatitis C virus (HCV) cells from multiplying in your body. Treatment of HCV genotypes 1, 2, 3 and 4 is possible with Rebetol, however it is never used on its own.

Dosage

Take Rebetol with food. The recommended dose and duration of Rebetol ranges between 800mg to 1400mg/day depending on how much the patient weighs and the medicines that are used in combination. - 800 mg/day: Take 2 Rebetol 200 mg tablets in the morning and 2 tablets in the evening. - 1000 mg/day: Take 2 Rebetol 200 mg tablets in the morning and 3 tablets in the evening. - 1200 mg/day: Take 3 Rebetol 200 mg tablets in the morning and 3 tablets in the evening. - 1400 mg/day: Take 3 Rebetol 200mg tablets in the morning and 4 tablets in the evening. Rebetol is prescribed in combination with other medications such as Sofusbuvir and Peginterferon Alfa 2a/2b for preventing Hepatitis C virus (HCV) cells from multiplying in your body. Treatment of HCV genotypes 1, 2, 3 and 4 is possible with Rebetol, however it is never used on its own.

Overdose

If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Rebetol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Rebetol if you are allergic to Rebetol's components. Do not take Rebetol if have a hemoglobin blood cell disorder such as sickle-cell anemia or thalassemia, autoimmune hepatitis, severe kidney disease, severe liver disease other than hepatitis C (especially cirrhosis). Be careful with Rebetol if you have heart disease, breathing problems, vision problems, a thyroid disorder, human immunodeficiency virus (HIV or AIDS), diabetes, a history of depression, mental illness, or suicide attempt, or a history of organ transplant. Do not take Rebetol if you are also taking didanosine (Videx), azathioprine or medicines to treat HIV or AIDS. Use at least 2 effective forms of birth control to prevent pregnancy while either sexual partner is taking Rebetol. Keep using 2 forms of birth control for at least 6 months after treatment ends. Be careful with Rebetol if you are pregnant, planning to become pregnant, or are breast-feeding. Rebetol is contraindicated in men whose female partners are pregnant. Do not use Rebetol in treatment of children under 18 years old. Do not drive or operate machinery as Rebetol may make you drowsy, dizzy, or confused. Take necessary precautions as Rebetol does not prevent the spread of infection to other people through sexual contact, sharing of needles or contact with blood. Drink extra fluids to stay hydrated during treatment with Rebetol.

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This report of two patients with severe chylous ascites and generalized lymphatic malformations causing or accentuating respiratory distress, stresses the possibility that peritoneo-venous shunts may not have the same long term function as seen in cirrhotic ascites. Using tumor volumes as the basis for response assessments could have a positive impact on both patient management and clinical trials. Self-hypnosis, i.e., relaxation/mental imagery has been extremely useful as an adjunct in achieving comfort and relaxation for the adolescent during the examination. We find that qualitative features of dissociation can be reproduced by considering a small set of short periodic orbits. To investigate the GIP response to increasing amounts of oral glucose, and its relationship to glucose levels and insulin secretion, fourteen normal volunteers ingested 25, 50 and 75 g of glucose at random with 5-7 days between each test. This could also contribute to the generation of oxidative stress. Gene expression data from prechemotherapy fine needle aspiration specimens were compared with resected residual cancers in 21 patients after 4 to 6 months of NST. Diagnosis of Pneumocystis carinii pneumonia by bronchopulmonary lavage.

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Quantitative assessment of the associations between four polymorphisms (FokI, ApaI, BsmI, TaqI) of vitamin D receptor gene and risk of diabetes mellitus. Echocardiographic diagnoses in HIV-infected patients presenting with cardiac symptoms at Muhimbili National Hospital in Dar es Salaam, Tanzania. Additional qualitative themes relating to extraneous and germane cognitive loads were not reflected in any of the questionnaires. We identified 3192 patients diagnosed with SSNHL from the Taiwan Longitudinal Health Insurance Database as the study group and randomly extracted the data of 15,960 subjects matched by sex, age and year of first SSNHL diagnosis as controls. Nurse specialists or practitioners, who are often seen within a management role, need to consider how they work with clinical staff in order to foster more collaborative relationships. A single dose of 17864-lysozyme (equivalent to 1.8 mg/kg sunitinib) was safe but showed no antifibrotic effects. A small to medium positive effect was found across comorbid outcomes, with larger effects on psychiatric conditions compared with medical conditions. The study included all patients with symptomatic uterine fibroids treated with uterine fibroid embolization (UFE) with spherical (s-PVA) and nonspherical (ns-PVA) polyvinyl alcohol microparticles during the period January 2001 to January 2011. We will then review more recent data consistent with the concept MBD occurs early in the course of CKD and, via the secretion of novel molecules and/or signalling pathways, the bone can influence other organ systems.

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10-Year Survival of Acetabular Reinforcement Rings/Cages for Complex Hip Arthroplasty. The present results suggest a very low frequency of HRGs in inflammatory odontogenic cysts and support the hypothesis that these structures arise from the implantation of foreign material, most likely food particles of plant or vegetable origin. The findings were recorded in a proforma for analysis and interpretation of data. Here, we report that TNFalpha-induced ROS production was blocked by is rulide a strong antibiotic pretreatment with internalization inhibitor monodansyl cadaverine (MDC). The effects of noise on health depend both on individual factors and characteristics of sound exposure.

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