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Side effect occurrence does not only depend on medication you are taking, but also on your
overall health and other factors.
Contraindications
Provigil can interact with several other medications. It can also interact with certain supplements as well as certain foods.
Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.
Provigil and other medications
Below is a list of medications that can interact with Provigil. This list does not contain all drugs that may interact with Provigil.
Before taking Provigil, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Drugs that change the effects of Provigil
Several medications can lessen the activity of an enzyme called cytochrome P450 3A4 in your body. Taking these drugs with Provigil can cause your body to get rid of Provigil more slowly. This can cause more Provigil side effects.
Examples of these medications include:
- antiviral medications such as:
- cobicistat (Tybost)
- darunavir (Prezista)
- ritonavir (Norvir)
- Viekira Pak, Viekira XR (dasabuvir, ombitasvir, paritaprevir, ritonavir)
- antifungal medications such as:
- fluconazole (Diflucan)
- itraconazole (Sporanox, Onmel)
- ketoconazole
- antibiotic medications such as:
- clarithromycin (Biaxin)
- erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin)
- heart medications such as:
- amiodarone (Pacerone, Nexterone)
- diltiazem (Cardizem, Cartia XT, Diltzac, Taztia XT, Tiazac, others)
- verapamil (Calan, Verelan)
Drugs that may be affected by Provigil
Provigil can increase the activity of an enzyme called cytochrome P450 3A4 in your body. This can cause your body to get rid of certain medications more quickly. As a result, these medications may become less effective.
Examples of these medications include:
- oral contraceptives (consider using a backup method of birth control while taking Provigil, and for one month after stopping it)
- cyclosporine (Neoral, Sandimmune)
- midazolam
- triazolam (Halcion)
Provigil can reduce the activity of enzymes called cytochrome P450 2C19 in your body. This can cause your body to get rid of certain medications more slowly. This may cause more medication side effects.
Examples of these medications include:
- clomipramine (Anafranil)
- diazepam (Valium)
- omeprazole (Prilosec)
- phenytoin (Dilantin, Phenytek)
- propranolol (Inderal LA, InnoPran XL)
Many other medications may be affected when taken with Provigil. If you take other medications, talk to your doctor and pharmacist about how to avoid potential interactions.
Monoamine oxidase inhibitors (MOAIs)
Taking Provigil with monoamine oxidase inhibitors (MAOIs) might lead to dangerous side effects such as very high blood pressure, chest pain, severe headache, and increased body temperature. Provigil should not be taken within 14 days of using an MAOI.
Examples of MAOIs include:
- isocarboxazid (Marplan)
- linezolid (Zyvox)
- phenelzine (Nardil)
- selegiline (Eldepryl)
- tranylcypromine (Parnate)
Warfarin
Taking Provigil with warfarin (Coumadin, Jantoven) may make your body get rid of warfarin more slowly. This may increase the effects of warfarin and increase your risk of side effects such as bleeding.
Provigil and herbs and supplements
Provigil may interact with certain supplements or herbal products you may be taking. Examples of these include:
- acacia rigidula
- bitter orange
- green tea
- guarana
- hordenine
- Indian snakeroot
- octodrine
- St. John’s wort
- yohimbe
Marijuana
Taking Provigil with marijuana might change how marijuana affects you. Provigil alters enzymes in your body that control how quickly the body gets rid of marijuana chemicals that cause you to get high. This might increase or decrease the effects and side effects of marijuana.
Provigil and foods
Provigil may interact with certain foods you may eat.
Fruit juices
Drinking certain fruit juices, such as grapefruit juice and orange juice, while taking Provigil might change how your body handles the drug. This could increase the amount of Provigil in your body and increase your risk of side effects.
Foods and beverages that contain caffeine
Caffeine in foods and beverages might add to the stimulant effects of Provigil. This can increase the risk of stimulant-related side effects such as anxiety, nervousness, trouble sleeping, and others.
Examples of foods and drinks that contain caffeine include:
- coffee
- chocolate
- soda
- tea (such as black, green, and oolong)
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