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Macrobid (Clarithromycin)

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Macrobid is an antibiotic used to treat various types of infections. It is effective in most infections of the respiratory tract, ear, nose, throat, lungs, and skin. It is also effective against a bacteria known as H. pylori, which is associated with peptic ulcer disease.

Other names for this medication:
Biclar, Clarimac, Claritron, Clariva, Clarix, Clarogen, Claromycin, Claron, Cleanomisin, Derizic, Fromilid, Hecobac, Helozym, Infex, Italclar, Kailasa, Karid, Klarimac, Klarith, Klarithrin, Klerimed, Krobicin, Laromin, Macladin, Nutabact, Odycin, Quedox, Rodizim, Uniklar, Zeclaren

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Also known as: Clarithromycin


Macrobid (generic name: clarithromycin; brand names include: Maclar / Klaricid / Klacid / Clarimac / Claribid) is used to treat many different types of bacterial infections affecting the skin and respiratory system, including: Strep throat, Pneumonia, Sinusitis (inflamed sinuses), Tonsillitis (inflamed tonsils), Acute middle ear infections, Acute flare-ups of chronic bronchitis.

It also is used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus (HIV)]. It is used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers.

It also is used sometimes to treat other types of infections including Lyme disease (an infection that may develop after a person is bitten by a tick), crypotosporidiosis (an infection that causes diarrhea), cat scratch disease (an infection that may develop after a person is bitten or scratched by a cat), Legionnaires' disease (a type of lung infection), and pertussis (whooping cough; a serious infection that can cause severe coughing). It is also sometimes used to prevent heart infection in patients having dental or other procedures.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Macrobid works by stopping the growth of or killing sensitive bacteria by interfering with their protein synthesis.


The recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days (up to the adult dose). Refer to dosage regimens for mycobacterial infections in pediatric patients for additional dosage information.

For the treatment of disseminated infection due to Mycobacterium avium complex (MAC), Macrobid Filmtab and Macrobid Granules are recommended as the primary agents. Macrobid Filmtab and Macrobid Granules should be used in combination with other antimycobacterial drugs (e.g. ethambutol) that have shown in vitro activity against MAC or clinical benefit in MAC treatment.

For treatment and prophylaxis of mycobacterial infections in adults, the recommended dose of Macrobid is 500 mg every 12 hours.

For treatment and prophylaxis of mycobacterial infections in pediatric patients, the recommended dose is 7.5 mg/kg every 12 hours up to 500 mg every 12 hours.

Macrobid therapy should continue if clinical response is observed. Macrobid can be discontinued when the patient is considered at low risk of disseminated infection.


Overdose symptoms may include severe stomach pain, nausea, vomiting, or diarrhea.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Protect from light. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Macrobid are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Macrobid if you are allergic to its components or to clarithromycin or to similar medicines such as azithromycin (Zithromax), dirithromycin (Dynabac), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), troleandomycin (Tao). Do not take Macrobid if you're pregnant or you plan to have a baby, or you are a nursing mother. Do not take Macrobid if you take astemizole (Hismanal), cisapride (Propulsid), ergot medicine such as ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), or dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), pimozide (Orap), terfenadine (Seldane). Do not take Macrobid if you have liver disease, kidney disease, myasthenia gravis, porphyria; personal or family history of "Long QT syndrome". Try to be careful with Macrobid usage in case you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. Avoid consuming alcohol. It can be dangerous to stop Macrobid taking suddenly.

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Our data suggest that acute severe TBI patients with administration of progesterone hold improved neurologic outcomes for up to 6 months. In control material, calcium deposits were prominent in nearly every synaptic vesicle, and to a lesser degree in mitochondria and the Golgi apparatus of pyramidal neurons and dentate granule cells. Calcipotriol plus betamethasone dipropionate scalp formulation is effective and well tolerated in the treatment of scalp psoriasis: a phase II study. Driven by the demands of several emergent technologies, efforts have been made to develop efficient, self-assembly-based methodologies for generating colloidal single crystals with well-defined morphologies. In this study the positions that will reduce the possibility that trochanteric ulcers will develop are identified. A vinyl stent for mucogingival graft procedures and post-surgical wound protection. The measured activities in the thyroid using the NaI(Tl) scintillation detector were compared with the estimated activities using the biokinetic models, in order to reach conclusion about the applicability of the portable scintillation counter for in vivo thyroid monitoring. Inadequate training or inattention to detail during this aspect of a study may result in unintentional adverse effects on experimental animals and confounded results. The patient completely recovered following treatment with topical and oral corticosteroids, and colchicine.

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Identification of enteric hormones with insulin-releasing activity. It may have therapeutic potential as an intravesical agent for nonmuscle invasive bladder cancer. Total polyphenols, antioxidant and antiproliferative activities of different extracts in mungbean seeds and sprouts. MRI is probably the best imaging method to study disease activity in RA, because it can study all the joints with similar efficacy, has been sufficiently standardised, and yields data on inflammation that can be quantified. High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney: DNA microarray analysis. In the present study, we proposed a new systematic approach for localizing the sources of correlated cross-frequency oscillations. The bromeliad factor that influenced mosquito abundance and assemblage structure was fullness. Effectiveness of the transparent sterile dressing vs standard to fix the peripheral venous catheter (PVC), on the incidence of phlebitis. DST shows high resistance to first- line anti-tuberculosis agents and quinolones. 53 tumour specimens were available for LOH analysis of 1p and 19q, using PCR amplification of multiple microsatellite markers.

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The experiments demonstrate that fixation of specimens with glutaraldehyde (GA) is leading in all cases to inconspicuously looking interstitial interfaces. Questionnaires were distributed amongst two Australian adult mental health clinics for completion either at the clinic (onsite), or externally (postal option), during March-May 2011. In these studies, we used endothelial cells (ECs) and 293 human embryonic kidney (HEK) cells expressing high-levels of surface ICAM-1. Implants are predisposed to infection even years after implantation, despite ostensibly being surrounded by innumerable macrophages as part of the host foreign body response. Clonal diversity and biofilm-forming ability of methicillin-resistant Staphylococcus pseudintermedius. Metabolic alterations have been suggested to have a crucial role in cancer development. The molecular mechanism that regulates virus-induced IFN-I production, particularly in tissue-resident immune cells, is incompletely understood. Further research with larger sample sizes is needed to confirm these findings.

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Clinicians often consider whether or not offenders with psychosis have a history of offending pre-dating the onset of their illness. Post-traumatic renal failure in military personnel in Southeast Asia. We have previously presented evidence that acyl dihydroxyacetone phosphate is converted to O-alkyl dihydroxyacetone phosphate via an endiol intermediate which then accepts a fatty alcohol to form O-alkyl dihydroxyacetone phosphate. Disruption of Circadian Rhythms and Delirium, Sleep Impairment and Sepsis in Critically ill Patients. Histamine and 5-hydroxytryptamine release in anaphylaxis of guinea-pig tissues. The regularity effect was found both when participants could and could not see their writing (Experiments 1 and 2) and was larger for low- than for high-frequency words (Experiment 3). The Gestapo prison for women in Lodz during the last phase of the Nazi occupation. Since Geminin is required in the blastocyst on E3.5, we employed shRNA to examine its role during postimplantation development. In fetuses, total GHRH-induced GH release decreased progressively over the 3 days.

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Controlled Allergen Challenge Facilities and Their Unique Contributions to Allergic Rhinitis Research. Sequence analyses and expression experiments were used to characterize the transferred genes. Also, cancer centers should formally commit to financing, at least partially, dedicated services, and existing programs for YWBC, guaranteeing their continuity. Thermomineral water baths are preferred by the elderly because of their positive beneficial effects over regulation of musculoskeletal system functions. Rib cage motion in ankylosing spondylitis patients: a pilot study. Cx26 and Cx32 were distributed inhomogeneously with no emphasis of expression in the types of tissues studied. Balancing venous thromboembolism and hematoma after breast surgery. Based on the results of our study, we speculate that LiaS is engaged in cross talk with one or more response regulators belonging to the same family as LiaR, enabling LiaS to regulate the expression of several genes coding for virulence factors.

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In the second case, a pseudoaneurysm was detected by angiography, obtained 4 days after surgery. In slow flows, the drag coefficients on a single-walled nanotube calculated from MD simulations were larger than those from the empirical equation or FE analysis. The differences in the mean gray value (MG), vascularization index (VI), flow index(FI), and vascularization flow index (VFI) were compared between benign and malignant lesions. In all settings, our method yields the highest sensitivity while maintaining relatively reasonable values for the specificity, false discovery rate and false non-discovery rate. For each gene, three expression phenotypes were obtained by different pre-processing methods. In the years 2004 and 2005, though no outbreak was reported, a definitely higher number of samples were received in the virology laboratory of A.I.I.M.S. We qualitatively interviewed 34 families (a family included a widow and 2 adult biological children) approximately 6-15 months after the death.

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Few studies have been published in the last decade on treatment outcomes of neutropenic oncology patients with Pseudomonas aeruginosa bacteremia. Structural birth defects associated with omphalocele and gastroschisis, Hawaii, 1986-2001. Age-related proteomic changes in the subventricular zone and their association with neural stem/progenitor cell proliferation. Effects and mechanisms of platelet-activating factor on the invasiveness of ovarian cancer cells in vitro. Morphologic observations of new type gosling viral enteritis virus (NGVEV) virulent isolate in infected duck embryo fibroblasts. Longer exclusive breastfeeding has a beneficial effect on cardiorespiratory fitness in children and adolescents. Similar to findings from the adult literature, the presence of negative affect may mark a more severe variant of loss of control eating in youth. They cover aromatics, heterocyclic aromatics, halogenated hydrocarbons, fuel oxygenates, alcohols, esters, and aldehydes. Mitochondrial diabetes is characterized by diabetes and hearing loss in maternal transmission with a heteroplasmic A3243G mutation in the mitochondrial gene.

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An Administrative Data Approach to Examining Perioperative Antibiotic Use in Head and Neck Oncologic Surgery. We used hazard ratios (HR) as an effect measure for overall survival (OS) and progression-free survival (PFS) and risk ratios (RRs) for response rates, treatment-related mortality (TRM) and adverse events. Brainstem infarct due to traumatic basilar artery entrapment caused by longitudinal clival fracture. Comparative clinical study in combination with Trypsin/chymotrypsin/P-amino-phenol. Many patients with a markedly enlarged prostate are often not amenable to minimally invasive therapies.

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Aches, pains and headache: an unusual combination of hypothyroidism, vitamin D deficiency, cervical radiculopathy and cortical vein sinus thrombosis. Furthermore, the ability of high-energy regions to accommodate relatively large numbers of rare or infrequent species may underlie any general tendency for the strength or shape of species-energy relationships to change with scale. Abnormal vascularization and sequestration of a lung segment (so-called intralobar lung sequestration). Binding of aggregated IgG BY HUMAN B lymphocytes independent of Fc receptors. Studies analyzing the effects of ISO 14001 certification and determinants of environmental performance tend to be based on a traditional and instrumental model of efficiency. Tamoxifen therapy in advanced breast cancer with positive estrogen receptors in postmenopausal women. Receptors for the Fc fragment of IgG on human peripheral blood lymphocytes in culture. Ribosome binding leads to marked suppression in the exchange rate of a number of fragments. Review: Genetically modified plants for the promotion of human health.

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Studies on the mode of attachment of H-Y antigen to the erythrocyte membrane reveal: (1) After several washes H-Y antigen can only be removed from male erythrocytes and not from other male cells such as granulocytes. We show that this mechanism is structurally and functionally closely related to recovery from C-type inactivation. The fundamental role of programmed cell death in host defense is highlighted by the multitude of anti-apoptotic strategies evolved by various microbes, including the well-known obligate intracellular bacterial pathogens Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae. The mean robotic estimated blood loss was 171 mL (range 30-500) compared with 150 mL (range 50-250) for the laparoscopic group. We detected a significant decrease in total hemoglobin levels as soon as one day after BV treatment in responder xenograft tumors (SK-NEP-1), but not in SK-NEP-1 control tumors or in non-responder control or BV-treated NGP tumors. These repolarization changes, referred to as cardiac memory, are initiated by locally increased angiotensin II (AngII) levels. This thickening, predominantly due to increased mesangial matrix material, extended to the glomerular hilum and the extraglomerular mesangium of the juxtaglomerular apparatus. These data indicate that positive environmental stimuli can be used to offset heightened responses to negative stimuli, particularly in individuals characterized by inherited 5-HTT downregulation and high sensitivity to environmental stimuli. Received social support had an effect on changes in sexual functioning, global QOL and health and functioning.

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Catheter ablation of left atrial linear lesions is an effective treatment option for perimitral flutter and is often used as a substrate modification approach for persistent atrial fibrillation. By modelling similar programmes internationally, such as those in Sweden, Norway, and the Netherlands, Canada would likely find the CCB to have greater relevance and accessibility to Canadian caregivers, particularly those caring for people with non-malignant advanced chronic illness. The aims of this study were to record the skills of patients 12 and 48 weeks after acute trauma and perform an analysis of the data to identify provisions of importance. To determine if a disease management programme for patients with coronary heart disease and heart failure represents an efficient use of health services resources. Because of issues with the accuracy of the serum retinol biomarker reflecting body stores, these results must be interpreted with caution. The status of hydronephrosis is an independent predictor of eligibility to receive adjuvant cisplatin-based does xanax help with alcohol addiction chemotherapy. Arizona occupational and physical therapists were surveyed about their needs for education in arthritis. We conducted a Medline search that covered the period from January 1969 to August 2005 for reports on the detection of SV40 DNA in human tissue samples.

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Inclusion of ATG-Fresenius in the conditioning regimen permits HSCT from mismatched unrelated donors without excess TRM and GVHD, resulting in identical OS and DFS of recipients of HLA-matched and HLA-mismatched grafts. In a cohort study spanning 21 years, all patients who underwent hysterectomy for gestational trophoblastic neoplasia (GTN) were included, and technical differences between hysterectomy performed in the reference center and those performed elsewhere were evaluated as well. Discoveries linking Lp(a) to oxidized phospholipid burden have implicated a proinflammatory role for Lp(a) hinting at a new mechanism underlying the association with CHD risk, which adds to previous atherogenic and thrombogenic mechanisms. Anethole, a potential glucotrol xl 5 mg antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent. Leukemia in mice and humans is accompanied by a marked deficiency of unesterified cholesterol in the surface membrane of leukemic cells as compared to normal leukocytes. The principal differences between the two populations were that the fracture patients had a lower forearm trabecular bone density, with lower bodyweight (both lower muscle mass and lower fat content), increased body sway, worse eyesight and reduced mental acuity.

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Metabolism and metabolites of dithiocarbamates in the plant pathogenic fungus Leptosphaeria maculans. Different forms of this correction term have been suggested before, which we here compare for a particular class of models. The composition of the polymer and relative amounts of polylactic acid, glycolic acid, and ethylene glycol were varied by controlling the precursor concentrations and reaction temperature. We speculated that the maturation state of the cells and the mode of PTH(1-34) administration would have an impact on the cellular response. The lesioned rats exposed to enriched housing for 10 days showed a significant degree of morphological plasticity in terms of enhanced dendritic branching and spine density. This review will summarize anticancer effect and mechanism of lycopene on gastric carcinogenesis based on the recent experimental and clinical studies. Homotransplant of the isolated pancreas in the rat, with suppression of exocrine secretion.

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Specimens of FFPE liver tissue may be used for the diagnosis of HCV infection, even if the tissue was obtained in a postmortem examination. Evaluation of the vascular endothelial growth factor (VEGF)-C role in urothelial carcinomas of the bladder. Repeated-measures analysis of variance (ANOVA) was employed for factorial analyses. An electronic survey evaluating the management of stage I seminoma patients was sent to Canadian radiation oncologists to determine their treatment recommendations and preferences. These findings partly explain the development of diabetes in patients receiving clevudine who might have a high susceptibility to mitochondrial toxicity. Our earlier work on HIV-1 reverse transcriptase (RT) suggested that the interaction between the gamma-phosphate of the incoming dNTP and RT residue K65 in the active site is not essential for dNTP insertion, implying that this polymerase may be able to insert dNDPs in addition to dNTPs. A review of the data on the structure and functions of mesangial cells (MC) and mesangial matrix of the kidneys in normal subjects under experimental conditions and in human pathology is presented. Serum was collected from the remaining sample for measurement of glucose concentrations with the laboratory analyzer. The concept that atherosclerosis is an inflammation has been increasingly recognized, and subsequently resulted in great interest in revealing the inflammatory nature of the atherosclerotic process.

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The relevance of short-course tuberculosis chemotherapy to the African situation. The permselective properties of PEM are determined by their microphase segregation into hydrophilic and hydrophobic domains. Sox10 expression alone is also sufficient to stimulate ectopic oligodendrocyte differentiation and weakly induce Nkx2.2 expression. The main cognitive domains affected are verbal memory, attention, and executive function. Evaluation of virulence factors and antifungal susceptibility patterns of different Candida species isolated from the female camel (Camelus dromedarius) genital tract. The absence of a suitable animal model for HIV infection is one of the major obstacles to the development of a preventive HIV vaccine. Tuberculous pleural empyema and the significance of surgical treatment. To determine whether having a partner deployed during wartime increased the stress levels in pregnant women and altered the attitudes toward pregnancy or changed birth outcomes. Despite the fact that the androgen receptor (AR) is known to be involved in the pathogenesis of breast cancer, its prognostic effect remains controversial. Chitosan is a biomatrix that is abundant, biocompatible, biodegradable, versatile, inexpensive and safe.

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Study of velocity and shear stress distributions in the impeller passages and the volute of a bio-centrifugal ventricular assist device. In contrast, the SSRI paroxetine has limited efficacy and is more at risk for inducing suicidal behavior. The interaction of recombinant PrP was more efficient against immobilized chondroitin sulfate of type A, and a linear correlation with concentration was demonstrated. Furthermore, it was found that hearing level equalized swept-tone OAEs (HL(eq) sTEAOE) can be acquired at very low intensities, which is not typical under current acquisition modalities. This system enables more efficient and systematic management of diabetes patients through self management and remote medical practice. Retention of poorly deformable RBC is an important determinant of pathogenesis in malaria and may also impact the clinical benefit of transfusion. Qualitative hepatic histopathology from all dogs was reviewed by a veterinary pathologist and assigned a semi-quantitative score to identify any abnormalities that may predict surgical outcome.

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She had undergone laparotomy for a perforated ulcer of the 3rd portion in the duodenum 3 years prior to this admission. Preocclusive perfusion area as a determinant of infarct size in a canine model. This paper describes five women and four men who sought psychiatric treatment within 6 months of attempted natural childbirth that did not proceed as planned. A new method using phase optimized LC (POPLC) for the analysis of steroids is described. On both FA and ICGA, large round drusen turned to hyperfluorescent in the late phase, while small radial drusen progressively decreased their fluorescence. Effects of 1,1,1-trichloroethane on a match-to-sample discrimination task in the baboon. In the remaining 2 cases, the diagnosis was made based on characteristic clinical findings for herpes simplex virus and varicella zoster virus (VZV). Among them, 110 anti-HCV antibody positive cases were diagnosed and subjected to viral RNA extraction, viral genotyping and viral load quantification using polymerase chain reaction (PCR) based techniques. The present study showed that both zinc sulfate and dapsone had significant therapeutic and prophylactic effects in controlling RAS, however, zinc sulfate had much more rapid and sustained action. This phenomenon was seen as early as the 1-week postoperative visit.

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