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Lunesta (Eszopiclone)
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Lunesta

This medication is used to treat a certain sleep problem (insomnia). It may help you fall asleep faster, stay asleep longer, and lessen how often you wake up during the night, so you can get a better night's rest. Lunesta belongs to a class of drugs called sedative-hypnotics. It acts on your brain to produce a calming effect. Use of this medication is usually limited to short treatment periods of 1 to 2 weeks or less. If your insomnia continues for a longer time, talk to your doctor to see if you need other treatment.

Other names for this medication:
Bexomer, Eszopiclone, Fulnite, Zolnite, Zopimin, Zopipure

Similar Products:
Zanaflex, Anafranil, Ceclor, Zithromax, Starlix, Rebetol, Asacol, Avana, Lasix

Also known as: Eszopiclone

Description

Lunesta along with other Z-drugs are the most commonly prescribed sedative hypnotics in the United States. Eszopiclone is not marketed in the European Union following a 2009 decision by the EMA denying it new active substance status, in which it ruled that eszopiclone was too similar to zopiclone to be considered a new patentable product. Eszopiclone is now available in a generic form in the United States as of May 2014. On May 15, 2014, the USFDA asked that the starting dose of Lunesta be lowered from 2 milligrams to 1 milligram after it was observed in a study that even 8 hours after taking the drug at night, some patients were not able to cope with their next-day activities like driving and other activities that require full alertness. It works by interacting with the GABA receptors.

Lunesta is slightly effective in the treatment of insomnia where difficulty in falling asleep is the primary complaint. Kirsch et al. found the benefit over placebo to be of questionable clinical significance. Although the drug effect and the placebo response were rather small and of questionable clinical importance, the two together produce a reasonably large clinical response. It is not recommended for chronic use in the elderly.

Dosage

Read the Medication Guide provided by your pharmacist before you start using Lunesta and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually just before you get into bed. Do not take it with or right after a high-fat or heavy meal since it may not work as well. The dosage is based on your medical condition, age, liver function, other medications you may be taking, and response to treatment. Do not take more of this medication than prescribed because your risk of side effects will increase. The starting dose is 1 milligram at bedtime as directed. That dosage lessens the risk of having trouble safely doing activities requiring alertness the next day (such as driving or operating machinery). Also, you may not be fully alert the next day, yet you think you are fully alert. If you are prescribed the 3 milligram dosage of Lunesta, you should not do activities the next day that require alertness. Ask your doctor or pharmacist for more details.

If you are an older adult or you have liver disease, a low dose will usually be prescribed to lessen the risk of being impaired the next day. Do not stop your medication without talking to your doctor or pharmacist.

Overdose

In clinical trials with Lunesta, one case of overdose with up to 36 mg of Lunesta was reported in which the subject fully recovered. Since commercial marketing began, spontaneous cases of Lunesta overdoses up to 270 mg (90 times the maximum recommended dose of Lunesta) have been reported, in which patients have recovered. Fatalities related to Lunesta overdoses were reported only in combination with other CNS drugs or alcohol.

exaggerations of the pharmacological effects noted in preclinical testing. Impairment of consciousness ranging from somnolence to coma has been described. Rare individual instances of fatal outcomes following overdose with racemic zopiclone have been reported in European postmarketing reports, most often associated with overdose with other CNS-depressant agents.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Flumazenil may be useful. As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. The value of dialysis in the treatment of overdosage has not been determined.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.

Storage

Store Lunesta at room temperature away from moisture and heat.

Keep track of how many capsules have been used from each new bottle of this medicine. Lunesta is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Side effects

The most common side effects associated with Lunesta are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Before taking Lunesta, tell your doctor if you are taking any of the following drugs: rifampin (Rifadin, Rifater, Rifamate, Rimactane); ketoconazole (Nizoral); or antidepressants, narcotic pain medications, muscle relaxers, seizure medications, or anti-anxiety medications.

This list is not complete an there may be other drugs that can interact with Lunesta. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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To objectively identify possible differences in the signal characteristics of benign and malignant soft tissue masses (STM) on magnetic resonance (MR) images by means of texture analysis and to determine the value of these differences for computer-assisted lesion classification. To determine racial and gender differences in long-term survival following ischemic stroke in a well-defined cohort of patients. Autoimmune diseases may therefore increase the risk of venous thromboembolism (VTE). We examined the influence of patient, surgeon and hospital characteristics on the use of minimally invasive radical prostatectomy vs radical retropubic prostatectomy. Evidence of both FasL and TRAIL-mediated signaling was seen after engagement of Jurkat cells by perforin-deficient human cytotoxic lymphocytes. We then used the detected state transitions to update target information in a mixture of Kalman filters that incorporated target position explicitly in the state, and used EMG activity to decode arm movements. Clinical studies on keratosis of normal oral mucosal epitheliums with inflammatory diseases.

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Study results showed that handling heavy items during pregnancy was associated with an increased risk of spontaneous abortion after adjusting for general characteristics of the participants and their work environment. An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts. Genomic in situ hybridization differentiates between A/D- and C-genome chromatin and detects intergenomic translocations in polyploid oat species (genus Avena). In this paper we review the state of the art in the field of liquid-crystal tunable guided-wave photonic devices, a unique type of fill-once, molecular-level actuated, optofluidic systems. Short-term changes in hsCRP and NT-proBNP levels in hypertensive emergencies. Capillary electrophoretic assay for nitrate levels in the vitreous of proliferative diabetic retinopathy. An organism presumably achieves the fully evolved state through adaptive changes in the kinetics of rate-controlling enzymes. 3) Unsatisfactory results from an operation are due to inappropriate indication for an anterior, posterior or combined fusion.

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For human paralogs, we demonstrate a global correlation between sequence identity and the binding of small molecules with equivalent affinity. The mineral concentrations in the 24-h samples from households on the same public water supply showed considerable variation, the differences sometimes being greater than those found in water samples from different sources. In addition, the acute MA challenge in adulthood decreased the time spent during social interaction suggesting an anxiogenic effect in the SIT model as well. Depending on the type of catheter and its purpose, the target was to position the tip either (a) at the cavo-atrial junction, or (b) in the lower third of the superior vena cava, or (c) in the upper part of the atrium. infections through microscopy is time consuming and less sensitive compared to PCR methods. Moreover, these experiments revealed, relative to controls, that upon incorporation into highly ordered microdomains, DHA-Bodipy underwent an increase in its fluorescence lifetime and molecular order. Two-thirds of the patients were adequately controlled with the single daily dose regimen and few side-effects were reported. For both speeds, the direction-dependent component of this adaptation modulation occurred in the same area, located significantly more dorsally compared with neural structures that were adapted in a direction-independent manner. Despite that a majority of the nursing content in the VIPS model could be expressed by terms in the ICF, the ICF needs to be developed and expanded to be functional for nursing practice. Neurological Wilson disease in children: a three years experience from Multan.

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By defining the demographic characteristics of the asthma population the Ministry of Health and the medical organizations concerned should be better able to manage the condition. These antigens show an absolute restriction to individual tumors, not being demonstrable on any other normal or malignant cell type. Using this technology, our initial data on SCCHN patient blood indicates that the presence of CTCs correlates with worse disease-free survival. On magnetic resonance imaging scans of 154 14-year-olds, we computed voxel-based morphometry to explore differences between frequent and infrequent video game players. Use of newer treatment modalities (liver assist devices and hepatocyte transplantation) is still in experimental phase.

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