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Femistra (Anastrozole)

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Femistra is an aromatase inhibitor approved by the U.S. Food and Drug Administration (FDA) to treat postmenopausal women diagnosed with advanced-stage or metastatic hormone-receptor-positive breast cancer.

Other names for this medication:
Altraz, Altrol, Anabrez, Anastrocare, Anastrozole, Anatero, Anazol, Armilon, Armotraz, Femistra, Femitraz, Qubol, Redest, Rimidex, Stazonex, Xenosoul

Similar Products:
Zebeta, Motilium, Aldara, Flonase, Avana, Zetia, Anafranil, Noroxin, Norvasc, Colcrys

Also known as: Anastrozole


Femistra is approved to treat certain types of breast cancer in women who’ve gone through menopause.

What breast cancer is

Breast cancer develops when cells in your breast start to grow and multiply (make more cells) more quickly than usual. With most breast cancers, the abnormal cells are encouraged to grow by the hormone estrogen.

If your breast cancer is stimulated by hormones, such as estrogen, certain tests will show that the cancer cells have receptors (attachment sites) for those hormones. This type of breast cancer is called hormone receptor-positive (HR+).

HR+ cancers can be treated with hormone therapies that lower the estrogen level in your body. And because most breast cancer is HR+, hormone therapies are also sometimes used to treat breast cancer whose receptor status isn’t known.

What Femistra does

Femistra is a hormone therapy that’s used to treat certain forms of breast cancer. It’s a type of drug called an aromatase inhibitor. Femistra works by stopping (inhibiting) the action of an enzyme called aromatase. (Enzymes are certain proteins that help chemical reactions to happen inside your body.)

The aromatase enzyme makes estrogen out of steroid hormones in your body, such as testosterone. Aromatase is found in various tissues, including your brain, fat, and skin.

Before menopause, estrogen is mainly produced by your ovaries. And just a small amount is made by the aromatase enzyme. But after menopause, your ovaries stop producing estrogen. At that point, the aromatase enzyme is the main way that your body makes estrogen. (And in men, estrogen is also mainly produced by the aromatase enzyme.)

By stopping aromatase from working, Femistra lowers the amount of estrogen in your body. This helps to stop estrogen from encouraging breast cancer to grow and spread.

How long does it take to work?

Femistra will start working soon after you begin taking it. But you won’t be able to notice this. Your doctor may order different kinds of tests during your treatment to check and see if the drug is working for you.


The following information describes Femistra dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Femistra comes as 1-mg tablets that are taken by mouth.

Dosage for breast cancer

The usual dosage of Femistra for breast cancer is one tablet taken once a day. It’s best to take your dose at the same time each day.

What if I miss a dose?

If you forget to take a dose of Femistra, take the missed dose as soon as you remember. However, if it’s almost time for your next dose, just skip the missed dose and take your next dose as usual. Don’t take two doses together to make up for a missed dose.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Femistra is meant to be used as a long-term treatment for breast cancer. If you and your doctor determine that Femistra is safe and effective for you, you’ll likely take it long term.

The length of time that you’ll take this drug depends on the type of cancer you’re using it to treat. Below we describe the typical length of time that Femistra is given. But to know for sure how long you should take Femistra, talk with your doctor.

For advanced breast cancer

If you’re taking Femistra to treat advanced breast cancer, you’ll usually take the drug for as long as your doctor feels this treatment is right for you. (With advanced breast cancer, the cancer has either spread to nearby areas or lymph nodes, called locally advanced breast cancer, or spread to other parts of your body, called metastatic breast cancer.)

For early breast cancer

If you’re taking Femistra as adjuvant treatment of early breast cancer, you’ll usually take the drug for at least 5 years. Adjuvant treatment is used to lower the risk of your breast cancer coming back or spreading after it’s already been treated with surgery. (With early breast cancer, the cancer hasn’t spread out of either your breast or the lymph nodes in your armpit.)

It’s not currently known if Femistra should be continued after these 5 years. And if so, it’s not known for how long after the first 5 years it should be taken.

Some studies found that breast cancer is less likely to come back if an aromatase inhibitor is taken for an additional 5 years after the first 5 years of adjuvant therapy. (Aromatase inhibitors are a class of medications.) With this approach to treatment, the drug would be taken for a total of 10 years. However, other studies didn’t show a benefit for extending the treatment beyond 5 the usual years.

In addition, one recent study found that taking Femistra for a total of 10 years didn’t provide any more benefit than taking it for a total of 7 years.

How long you take Femistra for early breast cancer will depend on how likely your breast cancer is to come back. It will also depend on your risk of side effects from treatment.


If you overdose Generic Femistra and you don't feel good you should visit your doctor or health care provider immediately.


Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Femistra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Femistra can interact with several other medications.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe.

Femistra and other medications

Below are lists of medications that can interact with Femistra. These lists do not contain all the drugs that may interact with Femistra.

Before taking Femistra, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Femistra and tamoxifen

Like Femistra, tamoxifen is a hormone therapy that’s used to treat breast cancer. But taking tamoxifen with Femistra can lower the amount of Femistra in your body. This can make Femistra less effective for you.

Because of this interaction, you shouldn’t take tamoxifen with Femistra. However, if recommended by your doctor, it’s fine to take Femistra after you’ve finished taking tamoxifen.

Femistra and drugs that contain estrogen

Taking Femistra with drugs that contain estrogen could make Femistra less effective for you. Because of this, you shouldn’t take these types of drugs while you’re using Femistra.

Examples of drugs that contain estrogen include:

  • hormone replacement therapy (HRT)
  • vaginal estrogen products, such as creams and tablets
  • birth control medications, such as pills, patches, and vaginal rings
If you have questions about using medications that contain estrogen with Femistra, talk with your doctor.

Femistra and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Femistra. However, you should still check with your doctor or pharmacist before using any of these products while taking Femistra.

For example, it’s possible that supplements such as red clover or wild yam could make Femistra less effective. (These supplements are used by some women to reduce menopausal symptoms, such as hot flashes.)

This interaction is possible because these supplements contain phytoestrogens, which are weak estrogen-like substances found in certain plants. There isn’t enough information available to say for sure whether taking phytoestrogens can affect your breast cancer treatment or not.

Be sure to talk with your doctor before taking any herbs or supplements with Femistra.

Femistra and foods

There aren’t any foods that are known to interact with Femistra. Talk with your doctor to find out if there are any foods you should avoid during Femistra treatment.

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