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Cozzar (Losartan)

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Cozzar is used to treat patients with chronic heart failure when therapy with specific medicines called angiotensin-converting-enzyme inhibitors (ACE inhibitors, medicine used to lower high blood pressure) is not considered suitable by your doctor. If your heart failure has been stabilised with an ACE inhibitor you should not be switched to Cozzar.

Other names for this medication:
Angibloc, Angilock, Arapres, Asart, Klosartan, Lakea, Lepitrin, Loben, Loortan, Lopernal, Loplac, Lopress, Lorista, Losakind, Losamet, Losap, Losapot, Losartanum, Losartec, Losartic, Losartil, Lostan, Lotar, Ocsaar, Omnitan, Prelow, Rasertan, Xartan

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Also known as: Losartan


Cozzar (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Cozzar is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Cozzar is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Cozzar 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Cozzar 25 mg, Cozzar 50 mg, and Cozzar 100 mg may also contain carnauba wax.


Take Cozzar tablets orally with or without food. Do not crush or chew it. Take Cozzar once or twice a day at the same time. If you want to achieve most effective results do not stop taking Cozzar suddenly.


If you overdose Cozzar and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Cozzar overdosage: fainting, feeling lightheaded, rapid heartbeat.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cozzar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Cozzar as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Cozzar. Correct volume or salt depletion prior to administration of Cozzar.

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Three family members, three co-workers, and 8 of the 10 pigs were MRSA positive. The long-term outcomes of patients with hepatocellular carcinoma after living donor liver transplantation: a comparison of right and left lobe grafts. The transmission electron microscope revealed loose structure of seminiferous epithelium, degenerative mitochondria, and increased amounts of lysosome, presence of numerous cytoplasmic vacuolation and chromatin in interstitial cell cytoplasm in the untreated group. Realistically, most of what we can do currently is treat the disabling symptoms of this dreadful disease. In contrast, EFMR spares transmitting males and affects only carrier females. Mathematical analysis of the relative peak heights showed that four peaks could be used to discriminate the three bacteria however they were cultured. We report a clinical case of a renal transplant patient in whom reversible acute encephalopathy and akinetic mutism developed.

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Cells from 2 types of stratified squamous epithelia were grown to confluence in vitro. Hyperhomocysteinemia may constitute a risk factor for patients with severe heart failure. Pakistan is a patriarchal society in which male opinion leaders play an important role in determining health-seeking behaviors pertaining to family planning (FP) among their respective communities. Neurons that respond strongly to simple visual stimuli - such as sinusoidal gratings - respond less well to the same stimuli when they are presented as part of a more complex stimulus which also excites other, neighboring neurons. These are more readily detectable when rat pituitary glands are used, and only by this technique can auto-antibodies directed against ACTH-secreting cells be detected. We present here results of studies on four patients (three men, one woman) who had had cadaver renal transplants and in whom renal artery stenosis and hypertension developed. CRF patients perceive physical exhaustion sooner during a motor fatigue task with minimal muscular fatigue. Use of re-esterified palm oils, differing in their acylglycerol structure, in fattening pig diets. Two naked-eye detection methods were developed for use in the field.

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Newer therapies include C1-inhibitor--both human plasma derived and recombinant--as well as contact system modulators such as ecallantide and icatibant. Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies. Costimulation blockade with antibodies directed against human CD40 and CD86 leads to prolonged kidney allograft survival in rhesus monkeys, but fails to induce permanent graft acceptance. The authors hypothesised that cigarette smoking is associated with coronary artery and aortic calcifications in Japanese and Koreans with high smoking prevalence. There was no change in mean arterial pressure or cardiac output (measured by thermodilution). We sought to evaluate carbohydrate intake, glycemic index (GI), and glycemic load (GL) and subsequent overall and hormone-receptor-defined breast cancer risk among postmenopausal women. Triggered by the new federal commitment announced by the Office of National Drug Control Policy (ONCDP) to encourage states to enact drugged driving per se laws, this article reviews the reasons to establish such laws and the issues that may arise when trying to enforce them. The modified product could be converted back into ferrichrome by mild acid or alkaline hydrolysis.

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Friends and neighbors: an active social network for adult and elderly hypertensive individuals. This study addressed the respective contributions of inhibition and working memory to two underlying components of flexibility, goal representation (as assessed by mixing costs) and switch implementation (as assessed by local costs), across the preschool period. It is readily accessed from pharmacy, patent medicine and provision shops as over the counter drug making it a potential drug of abuse, especially in children. (R)-4-Hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate is a useful chiral building block for the synthesis of biologically active compounds containing alpha-substituted alpha-amino acid moieties. Pain intensity and quality assessed by questionnaires are not suitable to discriminate TTH from TTH plus migraine. Thyrolipomas - Prevalence in Computed Tomography and Suggestions for Pragmatic Management. In recent years, aspirin has emerged as a powerful modality in prophylaxis of cardiovascular events, which may be linked to its inhibitory effects on angiogenesis.

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During the past decade, nonoperative treatment of leaks after bariatric surgery has been deemed acceptable in selected patients. The mutations affected highly conserved amino acids, p.I329T and p.D391V. Polypectomy rate is a valid quality measure for colonoscopy: results from a national endoscopy database. The anatase TiO2 ultrathin nanobelts were achieved simply by a subsequent calcination in air. Practice variability and efficacy of clonazepam, lorazepam, and midazolam in status epilepticus: A multicenter comparison. Pathophysiology of NRP is not fully understood but it seems to be related with microvascular damage. The single- and repeat-dose toxicity profile of IDX14184, a novel guanosine nucleotide prodrug with antiviral activity against hepatitis C viral infection, was characterized following once daily oral administration for durations up to 13, 26, and 32 weeks in mouse, rat, and cynomolgus monkey, respectively. To clarify alanine metabolism in the liver with special reference to gluconeogenesis, catheters were placed in hepatic, portal, femoral, and external jugular veins of six male mongrel dogs.

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A continuous, wearable, and wireless heart monitor using head ballistocardiogram (BCG) and head electrocardiogram (ECG). Genetic protection against hepatitis B virus conferred by CCR5Delta32: Evidence that CCR5 contributes to viral persistence. This study assessed the contribution of each separately in correctly identifying individuals at cardiovascular risk in the general population beyond traditional risk markers. The expression of Bad lead to the loss of RGCs following optic nerve crush. The ratio of lactate dehydrogenase (LD-1:LD-2) in serum was studied in 101 patients admitted to a coronary care unit. This paper reviews AIDS prevention initiatives in Canada and the United States in the 1980s and 1990s, and presents a content analysis of print materials used in Ontario during this period. Multivesicular endosomes or prevacuolar compartments (PVCs) are membrane-bound organelles that play an important role in mediating protein traffic in the secretory and endocytic pathways of eukaryotic cells. A multisubstrate analog, formed by joining coenzyme A with spermidine through an acetic acid linkage, serves as a strong inhibitor (Ki less than 10(-8) M) of the acetylation of spermidine and histones by histone acetylase purified from calf thymus.

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Recombinant LGALS3BP inhibits monocyte-derived fibrocyte differentiation, and immunodepletion of LGALS3BP from MDA-MB 231 conditioned media removes the monocyte-derived fibrocyte differentiation-inhibiting activity. Association between Experimental Bacterial Meningitis and Periapical Lesion. Maternal touch and talk for invasive procedures in infants and toddlers in the pediatric intensive care unit. Influence of streptozotocin-induced diabetes on blood pressure and on renin formation and release. Hepatoid adenocarcinoma is an extremely aggressive tumor with a poor prognosis, and effective chemotherapy has still not been established. Both patients were diagnosed with prolapsed vitreous asteroid hyalosis into the anterior chamber and managed with observation. Biometry was performed on the computed tomographical cross-sections of one human cervical spine. Diffuse and heterogeneous T2 hyperintense splenial lesions were characteristic of NMO. Criterion for extensional necking instability in polymeric fluids.

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Urinary extravasation and perlurethral phlegmon: clinical analysis of 100 cases. Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis. Latent class growth analysis zithromax generic price identified homogeneous subgroups with distinct trajectories of pain. Staining of mycobacteria without pre-heating in a modification of the Ziehl-Neelsen method. Prolonged exacerbation symptomatic duration is associated with poorer health status and a greater risk of a new event. Insulin-like growth factor I was administered, via intraperitoneal injection, to diabetic rats following tooth extraction. B-cell-activating factor of the tumor necrosis factor (TNF) family (BAFF) is critical for B-cell maturation and survival, and is implicated in the development and progression of CLL. Culture of osteogenic cells on a porous scaffold could offer a new solution to bone grafting using autologous human mesenchymal stem cells (hMSC) from the patient. By incubating each section with a specific antiserum, followed by incubation with a specific acid phosphatase isoenzyme of the prostate, the antibody binding site is visualized by staining for acid phosphatase activity in the glandular epithelial cells of the prostate and in the metastatic prostate carcinoma cells that involve the lymph node. All cells from both young and sensescent cultures exhibit a cytoskeletal network of actin microfilaments, intermediate (10 nm) filaments, microtubules, and interconnecting thin filaments (6-8 nm in diameter) which do not interact with heavy meromyosin.

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Differential effect of pentobarbital on chick neurons and astrocytes grown in culture. In AG of the gastric corpus and fundus, the plasma levels of pepsinogen I and/or the pepsinogen I/pepsinogen II ratio are always low. Here, we describe a child with postmeningitic deafness and XLA who underwent a cochlear implantation. For most patients within each yearly completer cohort, seizure reduction was maintained over time. The following experiments were conducted to determine when blurring does and does not result in enhanced remembering. Results of Wechsler-Bellevue intelligence scale and Wechsler memory scale testing at different stages in the disease. Correspondence, letter: An atypical response to radiation by the mud snail, Nassarius obsoletus. We need a detailed phenome in the phenomenon of genetics and congenital heart disease. The safety and function of an epithelium-free graft must be determined in a large animal model.

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This finding may be explained through thymidylate synthase inhibition by capecitabine. When used to achieve an Hb level within this range, erythropoiesis-stimulating agents (ESAs) can be expected to increase tumor oxygenation, and this may favorably influence sensitivity to treatment as well as quality of life. We also aimed to detect potential differences between patient self-assessment and psychiatrist evaluation in classifying the severity of depression. Although the risk for ESRD is higher in postmenopausal women according to the US Renal Data calcitriol 25mcg capsules System, the number of women who smoke is on the rise worldwide. Epithelial cells in malignant conditions release DNA into the extracellular compartment. A public-private-academic partnership developed and piloted a 10-step clinic breastfeeding support strategy and focused resources, training, and technical assistance on primary care clinics to help facilitate best-practice policy and environmental changes to improve clinic breastfeeding support. Furthermore, the pH 3-5 LIEF fraction and the unfractionated sample were separated by pH 3-6 2-DE and identified by MALDI-TOF/TOF MS, respectively. Normal pancreatic secretion in children with progressive familial intrahepatic cholestasis type 1. Mn/Ti-doped carbon xerogel for efficient catalysis of microcystin-LR degradation in the water surface discharge plasma reactor. Instantaneous dialyzer clearance does not reflect solute mass removal when body clearance is concerned.

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Pro-atrial natriuretic peptide (pro-ANP) level in patients with severe sepsis and septic shock: prognostic and diagnostic significance. The special case of spherical motion is presented and analysed in details. Hypothalamo-hypophyseal neurosecretory system in the early periods in the development of experimental myocardial infarct. We propose a step-by-step approach of the technique as practiced at experienced centers in North America. The demonstrated ability of HDV to infect already formed HCCs may facilitate development of novel strategies further dissecting the mechanism of liver pathogenesis associated with HDV infection. Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells. Programmable valves may be preferred in patients frequently experiencing proximal shunt failure. The objective of this study was to analyse the central motor conduction changes in relation to muscle contraction force during muscle fatigue and recovery in MS patients compared to healthy controls. Recent changes in the resuscitation guidelines in 2005 focused on minimizing interruptions during chest compressions. Removal of PHA from supernatants containing T-cell growth factor.

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intermedium chromosome to determine its structural organization. These results cast doubt on the utility of the DST in diagnosing depression that complicates advanced primary degenerative dementia. Wnt signaling plays an important role not only in development and morphogenesis of embryos but in pathogenesis of various disorders including cancers. Each of these point mutations also was individually constructed into the wt iNOS sequence. The proximal nerve root retracts, and the neural foramen fills with cerebrospinal fluid and eventually forms a pseudomeningocele. Four patients who presented with conductive and/or mixed hearing loss after retrosigmoid approach for removal of acoustic neuroma. Experimental approaches to the association of viruses to human cancer. Firstly it was to assess the suitability for tubal recanalization and factors predicting successful laparoscopic recanalization. Men with a normal foot posture were more likely to have PT compared to men with a pronated foot type. We obtain a shadow-free image by combining the base layer from the input RGB image and the detail layer from the intrinsic image such that the details of the intrinsic image are transferred to the input RGB image from which the correct luminance values can be obtained.

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Pre-pregnancy body mass index and weight gain during pregnancy in relation to preterm delivery subtypes. It was a cross-sectional study which included 309 subjects in the age range of 30-70years. An uncommon case of Idiopathic Intracranial Hypertension with diagnostic pitfalls. Bilateral inactivation of cholinergic BF neurons genetically targeted with archaerhodopsin prolonged SWS and decreased the probability of awakening from SWS in mice. Use of Cymbopogon citratus essential oil in food preservation: Recent advances and future perspectives. The ubiquitin-proteasome system and signal transduction pathways regulating Epithelial Mesenchymal transition of cancer. The pathologic findings of specimens obtained at radical retropubic prostatectomy and pelvic lymph node dissection were analyzed separately for all patients. The kinesiophobia, quality of life, and home-based program were assessed before and after physiotherapy. Similarities in the light chains of anti-gamma-globulins showing cross-idiotypic specificities. After 1958, however, the causes of most of the deaths from renal deltasone 10 mg disease were not those likely to be associated with exposure to lead.

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Based on our observations and clinical impressions we built a model of change that entails a series of stages and depicts change as a process. Time-resolved ultrafast photocurrents and terahertz generation in freely suspended graphene. Patients with a p16 gene inactivated by promoter methylation appeared to have a slightly lower tendency for local and regional recurrences. Two-step efficient synthesis of 5-methyluridine via two thermostable nucleoside phosphorylase from Aeropyrum pernix. Relationships among the perceived health status, family support and life satisfaction of older Korean adults. Nutrition has always played an important role in health and disease, ranging from common diseases to its likely contribution to the fetal origins of adult disease. Technically, these procedures could also be completed using ultrasound guidance, but existing evidence insufficiently supports this alternative imaging method, and it cannot therefore be recommended as a standard practice. The genetic variants described here will be a useful resource for future studies of genetic variation regulating performance traits and diseases in equids. Expression of glial fibrillary acidic protein, vimentin and smooth muscle actin was also performed.

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Four patients who were seen early in the series had wound dehiscences, two of which were infected. The aim of reporting this case was to identify the causative organism of post-traumatic endophthalmitis due to retained iron foreign body and to highlight the importance of carrying out diagnostic investigations. Some significant differences were found between the two groups when compared to control subjects in cortisol as well as prolactin biorhythms, and the cortisol suppression percentages were significantly lower in the endogenous than in the non-endogenous. Pars plana vitrectomy (PPV) or scleral buckling procedure (SBP) was performed as a primary re-attachment surgery. For this approach to succeed, it has to meet several conditions: it needs to target a gene essential for fertility. In particular, only a small number of dermal melanocytes in the two younger patients possessed extracellular sheaths and these were thinner than those of the three older patients. The case is of periodontal interest because the lesion occurred on the gingiva, a reliable diagnostic approach (Ultrasound Spectra Doppler Flow) was used and a conservative treatment using a sclerosing agent was employed. By including vergence accommodation, several important changes occur. The hepatocyte metabolism of 59Fe-labelled ferritin, haemoglobin-haptoglobin and transferrin has been examined in rats. We developed a high-affinity selective agonist (analogue 2) by removal of the intra-A chain disulfide bond and deletion of 10 residues from the N terminus of the A chain.

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Effects of increasing age, dosage, and duration of PTH treatment on BMD increase--a meta-analysis. Inhibitor of Growth 1 (ING1) is recognized as candidate tumor suppressor. Utilizing corrected balloon occlusive diameter may be of benefit in deciding the size of ASD occluder device. Short-term and long-term outcomes of single-incision versus multi-incision laparoscopic resection for colorectal cancer: a propensity-score-matched analysis of 214 cases. Among all patients with AOCLF, extracorporeal liver support with FPSA does not increase the probability of survival. When hepatoma cells transfected with a full-length apoA-V-green fluorescent protein fusion protein were cultured in medium that was not supplemented with oleic acid (OA), intracellular lipid droplet size and number were reduced compared with those of cells supplemented with OA.

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This approach has additional value for education and quality assurance. Students and preceptors disagree regarding the value of a minority of teaching behaviors. We find that the proposed methodology is more effective at estimating generic cymbalta and weight gain network topology than methods based on linear models. Bone density was reduced with the use of both enzyme and non-enzyme-inducing drugs, with both mono- and polytherapy, and was most severely reduced at the spine and hip with the use of enzyme-inducing drugs. These data demonstrate that HALN for renal cell cancer with tumor thrombus limited to the renal vein is feasible.

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