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Cozzar (Losartan)
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Cozzar

Cozzar is used to treat patients with chronic heart failure when therapy with specific medicines called angiotensin-converting-enzyme inhibitors (ACE inhibitors, medicine used to lower high blood pressure) is not considered suitable by your doctor. If your heart failure has been stabilised with an ACE inhibitor you should not be switched to Cozzar.

Other names for this medication:
Angibloc, Angilock, Arapres, Asart, Klosartan, Lakea, Lepitrin, Loben, Loortan, Lopernal, Loplac, Lopress, Lorista, Losakind, Losamet, Losap, Losapot, Losartanum, Losartec, Losartic, Losartil, Lostan, Lotar, Ocsaar, Omnitan, Prelow, Rasertan, Xartan

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Also known as: Losartan

Description

Cozzar (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Cozzar is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Cozzar is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Cozzar 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Cozzar 25 mg, Cozzar 50 mg, and Cozzar 100 mg may also contain carnauba wax.

Dosage

Take Cozzar tablets orally with or without food. Do not crush or chew it. Take Cozzar once or twice a day at the same time. If you want to achieve most effective results do not stop taking Cozzar suddenly.

Overdose

If you overdose Cozzar and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Cozzar overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cozzar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Cozzar as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Cozzar. Correct volume or salt depletion prior to administration of Cozzar.

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A continuous, wearable, and wireless heart monitor using head ballistocardiogram (BCG) and head electrocardiogram (ECG). Genetic protection against hepatitis B virus conferred by CCR5Delta32: Evidence that CCR5 contributes to viral persistence. This study assessed the contribution of each separately in correctly identifying individuals at cardiovascular risk in the general population beyond traditional risk markers. The expression of Bad lead to the loss of RGCs following optic nerve crush. The ratio of lactate dehydrogenase (LD-1:LD-2) in serum was studied in 101 patients admitted to a coronary care unit. This paper reviews AIDS prevention initiatives in Canada and the United States in the 1980s and 1990s, and presents a content analysis of print materials used in Ontario during this period. Multivesicular endosomes or prevacuolar compartments (PVCs) are membrane-bound organelles that play an important role in mediating protein traffic in the secretory and endocytic pathways of eukaryotic cells. A multisubstrate analog, formed by joining coenzyme A with spermidine through an acetic acid linkage, serves as a strong inhibitor (Ki less than 10(-8) M) of the acetylation of spermidine and histones by histone acetylase purified from calf thymus.

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Recombinant LGALS3BP inhibits monocyte-derived fibrocyte differentiation, and immunodepletion of LGALS3BP from MDA-MB 231 conditioned media removes the monocyte-derived fibrocyte differentiation-inhibiting activity. Association between Experimental Bacterial Meningitis and Periapical Lesion. Maternal touch and talk for invasive procedures in infants and toddlers in the pediatric intensive care unit. Influence of streptozotocin-induced diabetes on blood pressure and on renin formation and release. Hepatoid adenocarcinoma is an extremely aggressive tumor with a poor prognosis, and effective chemotherapy has still not been established. Both patients were diagnosed with prolapsed vitreous asteroid hyalosis into the anterior chamber and managed with observation. Biometry was performed on the computed tomographical cross-sections of one human cervical spine. Diffuse and heterogeneous T2 hyperintense splenial lesions were characteristic of NMO. Criterion for extensional necking instability in polymeric fluids.

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Differential effect of pentobarbital on chick neurons and astrocytes grown in culture. In AG of the gastric corpus and fundus, the plasma levels of pepsinogen I and/or the pepsinogen I/pepsinogen II ratio are always low. Here, we describe a child with postmeningitic deafness and XLA who underwent a cochlear implantation. For most patients within each yearly completer cohort, seizure reduction was maintained over time. The following experiments were conducted to determine when blurring does and does not result in enhanced remembering. Results of Wechsler-Bellevue intelligence scale and Wechsler memory scale testing at different stages in the disease. Correspondence, letter: An atypical response to radiation by the mud snail, Nassarius obsoletus. We need a detailed phenome in the phenomenon of genetics and congenital heart disease. The safety and function of an epithelium-free graft must be determined in a large animal model.

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This finding may be explained through thymidylate synthase inhibition by capecitabine. When used to achieve an Hb level within this range, erythropoiesis-stimulating agents (ESAs) can be expected to increase tumor oxygenation, and this may favorably influence sensitivity to treatment as well as quality of life. We also aimed to detect potential differences between patient self-assessment and psychiatrist evaluation in classifying the severity of depression. Although the risk for ESRD is higher in postmenopausal women according to the US Renal Data calcitriol 25mcg capsules System, the number of women who smoke is on the rise worldwide. Epithelial cells in malignant conditions release DNA into the extracellular compartment. A public-private-academic partnership developed and piloted a 10-step clinic breastfeeding support strategy and focused resources, training, and technical assistance on primary care clinics to help facilitate best-practice policy and environmental changes to improve clinic breastfeeding support. Furthermore, the pH 3-5 LIEF fraction and the unfractionated sample were separated by pH 3-6 2-DE and identified by MALDI-TOF/TOF MS, respectively. Normal pancreatic secretion in children with progressive familial intrahepatic cholestasis type 1. Mn/Ti-doped carbon xerogel for efficient catalysis of microcystin-LR degradation in the water surface discharge plasma reactor. Instantaneous dialyzer clearance does not reflect solute mass removal when body clearance is concerned.

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intermedium chromosome to determine its structural organization. These results cast doubt on the utility of the DST in diagnosing depression that complicates advanced primary degenerative dementia. Wnt signaling plays an important role not only in development and morphogenesis of embryos but in pathogenesis of various disorders including cancers. Each of these point mutations also was individually constructed into the wt iNOS sequence. The proximal nerve root retracts, and the neural foramen fills with cerebrospinal fluid and eventually forms a pseudomeningocele. Four patients who presented with conductive and/or mixed hearing loss after retrosigmoid approach for removal of acoustic neuroma. Experimental approaches to the association of viruses to human cancer. Firstly it was to assess the suitability for tubal recanalization and factors predicting successful laparoscopic recanalization. Men with a normal foot posture were more likely to have PT compared to men with a pronated foot type. We obtain a shadow-free image by combining the base layer from the input RGB image and the detail layer from the intrinsic image such that the details of the intrinsic image are transferred to the input RGB image from which the correct luminance values can be obtained.

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Effects of increasing age, dosage, and duration of PTH treatment on BMD increase--a meta-analysis. Inhibitor of Growth 1 (ING1) is recognized as candidate tumor suppressor. Utilizing corrected balloon occlusive diameter may be of benefit in deciding the size of ASD occluder device. Short-term and long-term outcomes of single-incision versus multi-incision laparoscopic resection for colorectal cancer: a propensity-score-matched analysis of 214 cases. Among all patients with AOCLF, extracorporeal liver support with FPSA does not increase the probability of survival. When hepatoma cells transfected with a full-length apoA-V-green fluorescent protein fusion protein were cultured in medium that was not supplemented with oleic acid (OA), intracellular lipid droplet size and number were reduced compared with those of cells supplemented with OA.

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