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Carim (Modafinil)

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Carim is a wake-promoting central nervous system (CNS) medication. Researchers don't know exactly how it works, but it may affect areas in the brain that control wakefulness and attention.

Other names for this medication:
Alertec, Carim, Dekast, Modafinil, Modafinilo, Modalert, Modapro, Modatec, Modavigil, Modfil, Modiodal, Provake, Renea, Vigia

Similar Products:
Adalat, Maxalt, Minocin, Levitra, Theolair, Anafranil

Also known as: Modafinil


Carim is prescribed for people who suffer from sleep disorders or narcolepsy - a pathological sleepiness associated with brain disorders. The active component of Carim is Modafinil. Researches have shown numerous advantages of using Modafinil as a stimulator in comparison with amphetamines. Carim doesn't cause addiction syndrome, it almost does not cause euphoria, reduces the peripheral nervous system tension and has very small effect on blood pressure.


The Carim dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Carim to treat
  • your age
  • other medical conditions you may have
Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Dosage for narcolepsy and sleep apnea

For daytime sleepiness caused by narcolepsy or obstructive sleep apnea, the typical dosage is 200 mg once a day in the morning. Higher doses are sometimes used, up to 400 mg daily. However, these doses may not be any more effective than 200 mg daily.

Dosage for shift work sleep disorder

For excessive sleepiness due to shift work sleep disorder, the typical dosage is 200 mg taken about one hour before the start of your work shift.

Dosage for people with liver problems

If you have severe liver problems, your doctor will likely prescribe a lower dosage. The recommended dosage for people with this condition is typically 100 mg daily.

Dosage for seniors

Seniors may be more sensitive to the effects of Carim, especially side effects. If you’re over 65 years of age, your doctor may prescribe a lower dosage.

What if I miss a dose?

If you miss a dose, take it as soon as you remember. Remember that Carim will keep you awake, so don’t take it unless you plan to be awake for several hours. If it’s close to your bedtime, skip the missed dose and take it the next day at the normal time.

Never try to catch up by taking two doses at a time. This can cause dangerous side effects.

Will I need to use this drug long-term?

Yes, Carim is usually taken long-term by people with narcolepsy or sleep apnea. These are chronic conditions that often require long-term treatment to improve symptoms of daytime sleepiness.


If you overdose Carim and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Carim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Carim can interact with several other medications. It can also interact with certain supplements as well as certain foods.

Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.

Carim and other medications

Below is a list of medications that can interact with Carim. This list does not contain all drugs that may interact with Carim.

Before taking Carim, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Drugs that change the effects of Carim

Several medications can lessen the activity of an enzyme called cytochrome P450 3A4 in your body. Taking these drugs with Carim can cause your body to get rid of Carim more slowly. This can cause more Carim side effects.

Examples of these medications include:

  • antiviral medications such as:
    • cobicistat (Tybost)
    • darunavir (Prezista)
    • ritonavir (Norvir)
    • Viekira Pak, Viekira XR (dasabuvir, ombitasvir, paritaprevir, ritonavir)
  • antifungal medications such as:
    • fluconazole (Diflucan)
    • itraconazole (Sporanox, Onmel)
    • ketoconazole
  • antibiotic medications such as:
    • clarithromycin (Biaxin)
    • erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin)
  • heart medications such as:
    • amiodarone (Pacerone, Nexterone)
    • diltiazem (Cardizem, Cartia XT, Diltzac, Taztia XT, Tiazac, others)
    • verapamil (Calan, Verelan)
Drugs that may be affected by Carim

Carim can increase the activity of an enzyme called cytochrome P450 3A4 in your body. This can cause your body to get rid of certain medications more quickly. As a result, these medications may become less effective.

Examples of these medications include:

  • oral contraceptives (consider using a backup method of birth control while taking Carim, and for one month after stopping it)
  • cyclosporine (Neoral, Sandimmune)
  • midazolam
  • triazolam (Halcion)
Carim can reduce the activity of enzymes called cytochrome P450 2C19 in your body. This can cause your body to get rid of certain medications more slowly. This may cause more medication side effects.

Examples of these medications include:

  • clomipramine (Anafranil)
  • diazepam (Valium)
  • omeprazole (Prilosec)
  • phenytoin (Dilantin, Phenytek)
  • propranolol (Inderal LA, InnoPran XL)
Many other medications may be affected when taken with Carim. If you take other medications, talk to your doctor and pharmacist about how to avoid potential interactions.

Monoamine oxidase inhibitors (MOAIs)

Taking Carim with monoamine oxidase inhibitors (MAOIs) might lead to dangerous side effects such as very high blood pressure, chest pain, severe headache, and increased body temperature. Carim should not be taken within 14 days of using an MAOI.

Examples of MAOIs include:

  • isocarboxazid (Marplan)
  • linezolid (Zyvox)
  • phenelzine (Nardil)
  • selegiline (Eldepryl)
  • tranylcypromine (Parnate)

Taking Carim with warfarin (Coumadin, Jantoven) may make your body get rid of warfarin more slowly. This may increase the effects of warfarin and increase your risk of side effects such as bleeding.

Carim and herbs and supplements

Carim may interact with certain supplements or herbal products you may be taking. Examples of these include:

  • acacia rigidula
  • bitter orange
  • green tea
  • guarana
  • hordenine
  • Indian snakeroot
  • octodrine
  • St. John’s wort
  • yohimbe

Taking Carim with marijuana might change how marijuana affects you. Carim alters enzymes in your body that control how quickly the body gets rid of marijuana chemicals that cause you to get high. This might increase or decrease the effects and side effects of marijuana.

Carim and foods

Carim may interact with certain foods you may eat.

Fruit juices

Drinking certain fruit juices, such as grapefruit juice and orange juice, while taking Carim might change how your body handles the drug. This could increase the amount of Carim in your body and increase your risk of side effects.

Foods and beverages that contain caffeine

Caffeine in foods and beverages might add to the stimulant effects of Carim. This can increase the risk of stimulant-related side effects such as anxiety, nervousness, trouble sleeping, and others.

Examples of foods and drinks that contain caffeine include:

  • coffee
  • chocolate
  • soda
  • tea (such as black, green, and oolong)

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Slow programmed freezing with DMSO as a cryoprotectant is efficient in maintaining the spermatogonia, Sertoli cells and stromal compartment during freezing, thawing and tissue culture. This article points out that faculty may not be as in touch with the needs of adult learners as they claim to be. To compare early postoperative clinical outcomes of photorefractive keratectomy (PRK) and lamellar epithelial debridement (LED). The structural information of phthalides was obtained via HPLC-MS/MS, which provides an accurate and fast method to identify the phthalides and provides more scientific information for quality control of Danggui. Clinical data from 36 subjects (two groups: normal and hypertensive) are collected to validate the model. Passive surveillance for Q fever in Nova Scotia and its neighboring provinces in eastern Canada indicates that the clinical manifestation of Q fever in the Maritime provinces is pneumonia and that incidence of the disease may fluctuate. All twins receive a series of detailed disease and environmental questionnaires.

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In the case of genetically modified organisms (GMOs) for food use, concern has focussed on the transfer of genes to other organisms, the potential for effects on non-target organisms, or on the health of humans and animals, and the likelihood of adverse effects on wildlife due to changes in farming practice. Children are just as likely to respond to a grammatically complete imitation prompt. The effects of lognormal amplitude fluctuations and Gaussian phase perturbations, in addition to local oscillator shot noise, are considered for both passive receivers and those employing active tilt-tracking systems to eliminate angle-of-arrival fluctuations. Analysis of differential absorption lidar from the space shuttle. Shoots were collected on two sites, an impacted site, Rosignano (Tuscany, Italy), and a pristine site, Tonnara (Corsica, France).

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Topography of the gastric mucosa in chronic gastritis (roentgenologic, endoscopic and histologic studies). These studies should also include data collection strategies that provide insight into how IPE affects changes in health care processes and patient outcomes. Restoration of Mating Ability to Sterile Mutants in Homothallic and Heterothallic Strains. The much debated need for randomised trials as new screening modalities emerge could be more easily handled if running screening programmes are regarded as natural platforms for testing out and evaluating presumed improvements in the service--including new emerging screening modalities. The distribution was bimodal with rates highest among 18-year-olds (732/100 000) and 1-year-olds (495/100 000). Bacillus subtilis, Neisseria subflava, and LYT coccus were found to undergo massive lysis after growth in media containing 0.01 to 10 mM NaF. To assess the leadership styles of frontline medical imaging supervisors and examine the relationship between leadership behaviors and motivational factors that influence job satisfaction of medical imaging staff in acute care facilities. Cubic mesoporous silica with large controllable entrance sizes and advanced adsorption properties. The purpose of the study was to examine the role of this reactive nitrogen species in lung ischemia-reperfusion injury. Rosai-Dorfman disease in an Asian Indian woman with classic generalized lymphadenopathy and nasal obstruction: a case report.

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Sensitivity of influenza A/New Jersey/8/76 (Hsw1N1) virus to amantadine-HCl. Dynamics of blood serotonin content in patients with cerebral circulatory disorders. Improvements in conventional processing methods and the development of innovative fabrication approaches are required because of the increasing specific demands on properties and morphology (cell size, size distribution and interconnection) for these materials, which strictly depend on the application considered. Factors associated with asthma among under-fives in Mulago hospital, Kampala Uganda: a cross sectional study. Multiple logistic regression was used to identify characteristics that predicted outcomes at 1 year. Number concentration and size distributions of submicron particles in jinan urban area: characteristics in summer and winter. Genetic analysis of enhancer of split, a locus involved in neurogenesis in Drosophila melanogaster. Biochemical analysis showed that rat hepatocytes responded to PPAR agonists with an induction of both peroxisomal and mitochondrial beta-oxidation (PBox and MBox) activities. Effects of intravenous captopril on inducible sustained ventricular tachycardia one week after experimental infarction in the anaesthetized pig.

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Of particular note is the lack of supporting data for the hypothesis that stretch is responsible for earlier activation of the uterus in multiple pregnancy. Optical absorption and infrared spectroscopy measurements provide evidence that the proteins adsorbed onto the SWNT undergo orientational changes of the helical segments in bR and helix conformational changes. LDP-392, a novel dual PAF receptor antagonist and 5-lipoxygenase (5-LO) inhibitor, has been identified. Promoting recovery in long-term institutional mental health care: an international Delphi study. Our findings emphasize that the level of mural cell differentiation and stabilization of the vascular wall significantly contribute to the response toward antiangiogenic therapy in melanoma. Most of the CXC chemokine genes are encoded in a cluster on chromosome 4q13.3-21.1, which has been identified in several genome-wide screens as being potentially associated with MS. Cat scratch disease should be considered in postliver transplant patients presenting with fever and liver lesions, especially if close contact with cats has occurred. Uptake due to binding to the ER, rather than intratumoral estrogen synthesis by aromatase or sulfatase, is the single most important correlate and a probable determinant of intratumoral E(2). This study demonstrates that lidocaine attenuates cytokine-induced injury of endothelial and vascular smooth muscle cells via mechanisms involving adenosine triphosphate-sensitive potassium channels.

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Cord ghrelin concentration increased in SGA infants due to state of prolonged undernutrition the source of ghrelin unknown may be from the mother placenta or fetal tissues. Five of the six eyes in this study had modern cataract surgery--phacoemulsification with a posterior chamber lens placed in the capsular bag. In rats with pFn levels decreased by antirat pFn serum, a single administration of pFn significantly increased the breaking strength of the skin and the bursting pressure of the abdominal wall compared to a control injection of albumin. Enteral nutrition problems after PEG occurred at a comparatively high rate. The incorporation of certain transport molecules (cargo) into the COPII vesicles is thought to be mediated by cargo receptors.

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Long QT interval in a patient after out-of-hospital cardiac arrest with hypocalcaemia, undergoing therapeutic hypothermia. These differentiated neurons were subjected to viability assays to illustrate their potential in future high-throughput screens. The extent of human sub-clinical adrenal effects from environmental chemical exposures is unknown, and the extent to which environmental chemicals may act as a contributory factor to human adrenal conditions following chronic low-level exposures will remain unknown unless purposefully studied. Postnatal loss of neurons in CNTF-deficient mice indicates a function of the factor also under physiological conditions. Food deprivation and refeeding effects on pineal indoles metabolism and melatonin synthesis in the rainbow trout Oncorhynchus mykiss. The two distinct autophagic processes were thought to be involved in the breakdown of SG and cell components in the cells of germinated cotyledon. We tested the hypothesis that early diffusion- and perfusion-weighted MRI (DWI and PWI, respectively) allows the prediction of malignant middle cerebral artery (MCA) infarction (MMI). Response of cats to familiar and unfamiliar human contact using continuous direct arterial blood pressure measurement. Considering the lack of information on the genetic structure of the fish of this species, the aim of the present study was to detect the genetic variability of Brycon hilarii through RAPD markers.

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Factors influencing the cell adhesion and invasion capacity of Mycoplasma gallisepticum. Reciprocally, ectopic expression of PU.1 reactivated these enhancers in fibroblasts. punctata was part of novel genetic structure corresponding to a mobile insertion cassette element. Given that school bullying is a widespread phenomenon in many countries around the world, the present results indicate that bullying should be considered a significant international public health problem. In group C, the free graft of periosteum took at 4 weeks with angiogenesis. Left ventricular (LV) diastolic dysfunction has been associated with impaired glucometabolic status. In this article, based upon his presentation in a concurrent session at the conference, Joe Amon argues that governments must immediately repeal these laws and policies. The PSG recordings were analysed manually by a blinded investigator. Laparoscopic adjustable gastric banded plication: evolution of procedure and 2-year results.

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The tarsal strip technique is a relatively simple technique that oral and maxillofacial surgeons can use to manage lower lid malposition, such as scleral show and ectropion. A common neural-network model for unsupervised exploratory data analysis and independent component analysis. The supply and demand for dentists in aceon drug Puerto Rico: the years 1985, 1990 and 1995. This review discusses aspects of antiplatelet therapy for pediatric patients. A novel epistatic interaction at two loci causing hybrid male sterility in an inter-subspecific cross of rice (Oryza sativa L.). The function of the entero-insular axis and abnormalities of circulating gastric inhibitory polypeptide (GIP) were examined in mice for 40 days after induction of streptozotocin diabetes. The transgene locus KH15, which is highly susceptible to silencing in Arabidopsis thaliana, contains two inversely repeated beta-glucuronidase (gus) genes separated by a palindromic sequence and has a low GUS activity, was found to be heavily methylated in the gus coding sequence and in the center of the inverted repeat. Comparison of three definitions of metabolic syndrome in 60-year-old men and women.

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The transcription factor Neurogenin3 (Ngn3) is required for islet-cell type specification. Ninety-one stable outpatients with schizophrenia and 55 healthy controls were assessed with a neuropsychological battery. Computer fitting of the experimental data to this model generates various thermodynamic parameters for the folding-unfolding process. Midkine is a NF-kappaB-inducible gene that supports prostate cancer cell survival. Recent advances in preparing state-of-the-art large display libraries are then reviewed. The patient also had calcification of the falx cerebri and an unusual median palatal groove, which has not been reported in Hajdu-Cheney syndrome before. To identify the discontinuous epitope of this mAb, we used phage display, mutant analysis, and peptide modeling. Delay-dependent guaranteed cost control for uncertain stochastic fuzzy systems with multiple time delays. The relative role of thymus-derived (T-) lymphocytes and bone marrow-derived (B-) cells in acquired immunity to salmonellosis was examined in mice.

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The PAI-1 mRNA level in connective tissues from 15 healthy volunteers was similar to the level in tumor-adjacent normal tissues, but the level in epithelium was 5- to 10-fold lower. The 57-kDa protein could be resolved into at least three components (pI 5.6-5.9), and the 54-kDa protein into at least two components (pI approximately 5.6). Application of the coefficient of interparticle friction and the cohesion obtained by cohesion parabola method to pharmaceutical technology. Fast rotational computed tomographic scanning techniques allow an accurate appreciation of the diameter of the colon, the presence of severe necrotizing mucosal change, and the detection of unsuspected intramural colonic air (pneumatosis coli) in cases of severe necrotizing ulcerative colitis. Long-term studies in a larger group of patients are needed to substantiate these results. The plasma peak level was 5 times higher, and the area under curve (AUC) was 10 times higher, in 3H-FX-administered than what happens if you overdose on risperdal 3H-NIV-administered mice. We conclude that UVB inflammation produces a dose-dependent hyperalgesic state sensitive to established analgesics.

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there should be a prognosis established based on kinetic energy of the injury and not only with Glasgow Scale. Additionally, CtxA induces junctional damage, weight loss, and dye leakage in the Drosophila gut, contributing to lethality from live V. Here, we report data related to two-photon interactions after stop to take duphaston tablet when the period will start that occur with the following fluorescent molecules: Indo-1, Rhodamine 6G, Fluorescein, and Pyrene. Clinically, it is impractical to obtain pre- and post-treatment images. The method, based on a two-polarization scheme, provides sufficient optical isolation between the TEA laser pulse and the probing laser beam to prevent anydamage or saturation of the controlling system. As background noise, the simulations include simulated Gaussian noise and fMRI data without stimulation.

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Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2. To select higher thrombolytic and lower toxic single component of earthworm fibrinolytic enzymes (EFE). The relationship of the position of crown margins to gingival health. This has implications for the interpretation of results, which in turn has implications for the widespread use of HER2 testing. Synthesis and electrochemical albenza drug behaviour of beta-halodehydroamino acid derivatives.

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