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Calmef (Alprazolam)

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Alprazolam, available under the trade name Xanax, is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder, but also in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Calmef, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Calmef is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Acalm, Alpracon, Alpraday, Alprasan, Alprastan, Alsert, Ansilumirm, Anxilam, Anxitab, Azolam, Belfa, Destres, Elzopam, Enxolam, Fluzolam, Indolam, Onapract, Resolin, Richpram, Rozin, Selamb, Sertamax, Tenolam, Xycalm, Zodia, Zolorest, Zopain

Similar Products:
Decadron, Anafranil, Aldara, Effexor, Skelaxin, Asacol

Also known as: Alprazolam


Calmef is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety. Calmef is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

You should not use Calmef if you have narrow-angle glaucoma, if you also take itraconazole or ketoconazole, or if you are allergic to Calmef or similar medicines (Valium, Ativan, Tranxene, and others).

Alprazolam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Do not drink alcohol while taking Calmef. This medication can increase the effects of alcohol. Alprazolam may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.


Take this medication by mouth as directed by your doctor. Dosage is based on your medical condition, age, and response to treatment. Your dose may be gradually increased until the drug starts working well. Follow your doctor's instructions closely to reduce the risk of side effects.This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as seizures) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Report any withdrawal reactions immediately.Along with its benefits, this medication may rarely cause abnormal drug-seeking behavior (addiction). This risk may be increased if you have abused alcohol or drugs in the past. Take this medication exactly as prescribed to lessen the risk of addiction.When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.Tell your doctor if your condition persists or worsens.


If you have been prescribed Calmef for medical reasons, the best way to avoid a Calmef overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Calmef consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Calmef are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before taking Calmef, tell your doctor or pharmacist if you are allergic to it; or to other benzodiazepines (such as diazepam, lorazepam); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: severe lung/breathing problems (such as COPD, sleep apnea), liver disease, kidney disease, drug or alcohol abuse, glaucoma.This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this drug, especially loss of coordination and drowsiness. These side effects can increase the risk of falling Calmef is not recommended for use during pregnancy due to the potential for harm to an unborn baby. Consult your doctor for more details.This drug passes into breast milk and may have undesirable effects on a nursing infant. Therefore, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

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Three lipopeptides, ciliatamides A-C ( 1- 3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Laparoscopic management of ureteropelvic junction obstruction by division of the aberrant vein and cephalad relocation of the crossing artery: a long-term follow-up of 42 cases. An approach to stability criteria of neural-network control systems. Characterisation and glucoregulatory actions of a novel acylated form of the (Pro3)GIP receptor antagonist in type 2 diabetes. PVs also differed from their parental strain in swimming motility and biofilm formation, and interestingly, all assessed variants were less virulent than their corresponding parental strains in seed transmission assays. The desmoplastic subtype of MB is associated most commonly with NBCCS. The development of new therapeutics for sleep disorders is increasingly dependent upon understanding the basic brain circuitry that underlies sleep-wake regulation, and how it may be pharmacologically manipulated.

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Whereas the addition of PrPSc increased cellular cholesterol levels and was predominantly found within lipid raft micro-domains, PrPSc-G-lyso-PI did not alter cholesterol levels and most of it was found outside lipid rafts. In this paper an artificial neural network (ANN) based radar target classifier is presented, and its performance is compared with that of a conventional minimum distance classifier. Multiphoton fluorescence is used for the direct observation of a new class of breathers in waveguide arrays, which are a coherent superposition of Floquet-Bloch solitons of different bands. These immunohistochemical findings are characteristic of anaphylactoid purpura and suggest that IgA is involved in the pathogenesis of anaphylactoid purpura and may operate through the alternate pathway of the complement system. In patients with central lung cancer, lobectomy can be achieved without pneumonectomy by surgical reconstruction of the pulmonary artery (PA). Collagen I is the predominant matrix constituent in many tissues and aggregates with other collagens and/or fibril-associated macromolecules into distinct types of banded fibrils. The lack of causal homogeneity in the aetiology of this disorder presents problems for predicting and preventing it, making the ischemic stroke in childhood a real dilemma for the clinician. The total pedicle length ranges from 10 to 14 cm, and the size ranges from 18 x 8 to 21 x 10 cm.

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Metallothionein in bladder cancer: correlation of overexpression with poor outcome after chemotherapy. Most characteristic of these cells was the presence of numerous, large, electron-lucent vesicles which often were packed in the cytoplasmic processes that were located subjacent to the follicular cells and close to the blood capillaries. Surface modified polystyrene microparticles were administered to human-derived macrophages (MPhis) and dendritic cells (DCs) in vitro to evaluate the phagocytosis activity of each cell type. Analysis of the expression and function of the small heat shock protein gene, hsp27, in Xenopus laevis embryos. Both optimised sample preparation and experimental conditions for faster GC are the future perspective of trace analysis. fumigatus together with comparative analysis of yeast cell wall data have shown that beta 1-3 glucan branching and chitin-beta 1-3 glucan binding are essential exocellular enzymatic steps in cell wall biosynthesis.

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Venous PCO 2 and cardiac output obtained from rebreathing curves: by extrapolation or by a plateau method?. Therapy of subclinical (subdiagnostic) syndromes of schizophrenia spectrum. Patterns in the promoter sequences within a species are known to be conserved but there exist many exceptions to this rule which makes the promoter recognition a complex problem. One result of such drug pressure however is that evolutionary change may result, and it is incumbent on scientists during monitoring and evaluation of control programmes to ensure that such changes are recognised. The process of adaptation of culture microorganisms to the medium acidity has been investigated by the stabilization of growth rate method. The gaps identified suggest the need for continuing attention by the academic medical community to address the challenges presented by ICOI more consistently and comprehensively. The cell surface markers like IL-2 receptor (CD25) were also down-regulated together with decreased production of pro-inflammatory cytokines of IL-6, TNF-alpha and IFN-gamma. From impulse response waveforms and baseband frequency responses, it was observed that mode mixing effects became more noticeable as the mode coupling coefficients increased.

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Experiments 2A, 2B, and 3 were similar in format to Experiments 1A and 1B, but the trivia stimuli were replaced with word puzzles, which were expected to be better suited to inducing a feeling of having known it all along, because answers to trivia questions typically seem arbitrary, whereas word puzzles often give rise to ah-ha experiences. The 36 Aeromonas isolates examined by RAPD-PCR generated RAPD fingerprints with majority of the bands ranging from about 250 to 2800 bp. To further improve drug efficacy in the lungs, it may be advantageous to control aerosol deposition and target aerosols to diseased or disease-causing lung tissue and cellular structures in order to maximize drug potency and minimize side effects in unaffected tissue. The method involves photosensitization of drugs and fluorescent dyes, such as hematoporphyrin derivative (Hpd), after preferential incorporation by neoplastic cells. For example, tertiary amides have no hydrogen bond property at all, secondary amides are rather weak hydrogen bond acids, and primary amides are stronger hydrogen bond acids than are alcohols as solvents. A soil isolate of actinomycete, strain SANK 60684, was found to produce new enkephalinase B inhibitors, propioxatins A and B. Instrumental requirements and artefact sources within the contrast formation mechanisms and within the numerical reconstruction are assessed.

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Two cases of occupational accident in confined spaces, recently occurred in the harbour of Venice, are reported in this article. The vascular status of all patients was unchanged from beginning to end of the period of observation. Calculated parameters for the glucose curve of the CGIT had low repeatability, whereas the parameters for the insulin curve had high repeatability. Impedance and relative displacements of relaxed chest wall up to 4 Hz. The secretion of prolactin from the adenohypophysis is tonically inhibited by dopamine that is released into the hypophysial portal blood from terminals of tuberoinfundibular neurons located in the external layer of the median eminence. We find that endogenous SMC3 and newly expressed hRAD21 co-localize on chromosomal axes, sites where sister chromatids are tightly paired. Maturation of functional type III secretion machinery by activation of anaerobic respiration in enterohaemorrhagic Escherichia coli. Diagnostic value of triple-phase bone scintigraphy for the diagnosis of infection around antibiotic-impregnated cement spacers.

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Monoclinic S8 , an uncommon allotrope of sulfur at room temperature, can be formed when common orthorhombic S8 is heat-treated under enclosed environments in nanometer dimensions. Personality and perfectionism in chronic fatigue syndrome: a closer look. The glycan profile of endothelial cells in the present of tumor-conditioned medium and potential roles of beta-1,6-GlcNAc branching on HUVEC conformation. The indirect enzyme-linked immunosorbent assay (ELISA) for detection of immunoglobulin M (IgM) antibodies to Treponema pallidum in sera of syphilitic patients is complicated by false positive reactions due to the interference of IgM rheumatoid factor (IgM-RF) activity and the presence of treponemal IgG antibodies. We determined the safety and efficacy of optical urethrotomy using a spongiosum block with sedation for anterior urethral stricture in a comparative, nonrandomized study.

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In this classification and score the main pathological findings of the complete leg are included (coxa-femur-patella-tibia-fibula-pes), with specific importance of the tibia. Target-derived NGF promotes the phenotypic maintenance of mature dorsal root ganglion (DRG) nociceptive neurons. The association of the ratio of waist to hip girth with blood pressure, serum cholesterol and serum uric acid in children and youths aged 6-17 years. Applying a diffusion based model in which xi scales as xi approximately D(-0.25).C(-0.5), we extracted the DNA diffusion coefficient D approximately 2 x 10(-7) cm(2)/s. Effect of a hands-free wire on specific absorption rate for a waist-mounted 1.8 GHz cellular telephone handset. However, they seem to display contrasted levels of genetic diversity, suggesting they have distinct demographic histories and/or life-history traits. However, large prospective studies are needed to confirm these results and to better understand the meaning of PSA variations. Fourteen mongrel dogs were subjected to 45 min of superior mesenteric artery (SMAO) or vein occlusion (SMVO), and observed for 120 min after reperfusion.

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Cyclin E, HER-2 and p53, are considered as major prognostic markers in breast cancer. The apoptotic debris can be encountered by the macrophage in amaryl 30 mg multiple anatomical compartments including the circulation but also in areas of intense cell death such as in the thymus and germinal center were tight regulation is important. Cytotoxicity of lissoclibadins and lissoclinotoxins, isolated from a tropical ascidian Lissoclinum cf. In this study, we investigated the anthocyanins isolated from Vitis coignetiae Pulliat for their potential anti-proliferative and apoptotic effects on human leukemia U937 cells. In a previous study, we demonstrated a network of correlations of cortical thickness among specific cortical areas and speculated that these correlations reflected an underlying structural connectivity among those brain regions. Psychological support from early stages and throughout the evolution of PD is fundamental. Age- and gender-specific reference values of estimated glomerular filtration rate in a Caucasian population: Results of the Nijmegen Biomedical Study.

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Chondrocytes isolated from human OA knee cartilage were cultured and the effect of HA on both spontaneous and anti-Fas-induced apoptosis was evaluated. Together with the Greek version of STAI scale, the patients also completed the anxiety subscale from the Hospital Anxiety and Depression scale (HAD). Diabetes also lowered total antioxidant potential and heparan sulphate levels in cardiac and arterial tissues, and serum ferroxidase activity, whereas it elevated urinary heparan sulphate excretion. To get insights about ATRA regulation of miRNAs, we searched for ATRA-modulated transcription factors binding sites in the upstream genomic region of the let-7a-3/let-7b cluster and identified several putative nuclear factor-kappa B (NF-kappaB) consensus elements. Amniotic fluid volume and its relationship to fetal fluid balance: review of experimental why is xanax a schedule iv drug data.

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Since bacterial membranes do not contain cholesterol, this finding may partly explain the selective toxicity of sarcotoxin I to bacteria. Mutants defective in mating-type conversion were isolated from ascospores of a perfect homothallism strain having the HO HMRaHMLalpha genotype. Although recognition of head and cervical spine injuries has resulted in significant reductions of catastrophic neurological injuries, especially in the cervical spine, further advances to decrease the incidence and long-term sequelae of head and neck injuries are needed. The only His-Asp proteins identified in the two-hybrid screen were five members of the histidine kinase superfamily. Vibration analysis of maxillary removable partial denture using three types of major connectors. Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration. Firstly a regression-based model employing estimates of pairwise relatedness was applied, and secondly a Markov Chain Monte Carlo (MCMC) amiloride and hydrochlorothiazide brand name canada procedure was employed to reconstruct full-sibships and hence an explicit pedigree.

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Consistent with this, GCN4 expression was reduced by isoleucine and valine. There was no significant difference in the success rate between the DCPC and AGV implantation in neovascular glaucoma treatment. The apoptosis could be markedly attenuated by N-acetylcysteine (NAC, a free radical scavenger), which confirmed the involvement of oxidative and nitrative stress in the process leading to HepG2 cell apoptosis by APRTP-Js treatment. Instead, absolute dispersal barriers appear to be the best predictor of regional genetic structure in this species. Cosecretion of DnaJ also dramatically increased the amount of a second model protein, native proinsulin, in the periplasm. Clinical presentation and diagnostic sensitivity of laboratory tests for Strongyloides stercoralis in travellers compared with zithromax 100 mg per 5 ml immigrants in a non-endemic country. This study examines the clinical results of a patient cohort undergoing autologous chondrocyte implantation and elucidates factors associated with subjective improvement after implantation.

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These 19-24 nucleotide regulatory RNA molecules have essential roles in multiple faucets of adaptive immunity, from regulating the development of the key cellular players to the activation and function in immune responses. Moreover, DNA-binding and proliferation-associated genes, which are down-regulated during differentiation of the leukemic cells, demonstrated elevated levels in the VCP/p97 siRNA transfectants. Disruption of these motifs results in ER exit and surface expression of KA2 homomeric receptors that remain nonfunctional. Concentrations of cationic surfactants in aqueous solutions have been estimated on the basis of changes in the color of gold nanoparticles, used as reporter probes. Moreover, the chlorophyll a concentration was higher in the surface water and lower in the bottom water as found in this study, implying that water quality was affected by stratification.

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Overall, the countryside-SAR model had a better fit to the data showing that habitat composition determines species richness across scales. However, information regarding the cost-effectiveness of HBO2T is still extremely limited. We used multivariate logistic regression models to estimate the associations between smoking and neighborhood-level factors, independent of individual factors. Surgical resection is the single most important predictor of survival. Prospective studies are warranted to define optimal immunosuppression for recipients transplanted for hepatitis B. Taken together, this assay could provide a rapid screening tool for any adenovirus-based gene therapy trial. Results also indicated that secondary treatment plants are comparable to the primary treatment plants in removing EDCs from the final effluents. Opioid agonist and antagonist was also used in addition to methionine-enkephalin itself. The results of a number of recent studies show that mutation rates in the offspring of irradiated parents are substantially elevated, however, the effect of parental genotype on transgenerational instability remains poorly understood. The use of autotransfusion with a centrifugal cell washer in a series of 76 cases is reviewed.

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The PAH profile suggested that coal combustion and biomass burning were primary PAH sources. Convergence results are provided, as well as theoretical examples and experiments. Decreased activity of MTHFR leads to reduction of 5-methyltetrahydrofolate, the main methyl donor for methionine synthesis necessary for synthesis of S-adenosyl-methionine (SAM). The break of the equilibrium between pro-inflammatory agents and anti-inflammatory ones in haemodialysis patients leads to anemia of chronic inflammation, characterized by a functional iron deficiency. Nucleotide sequence of the precore/core gene and X gene of hepatitis B virus DNA in asymptomatic hepatitis B virus carriers who are negative for serum hepatitis B core antibody. The effectiveness of pelvic and para-aortic lymphadenectomy in the morbidity of patients affected by early-stage endometrial carcinoma (EC) is the subject of this study. We use a set-covering algorithm to identify optimal cliques and a Boolean function that identifies etiologically heterogeneous groups of individuals. The generation of both pyrimidines and triazines in comparable yields from urea, together with a possible role for triazines as alternative nucleobases, opens new perspectives on the prebiotic chemistry of informational polymers. Use of the spring graft for prevention of midvault complications in rhinoplasty. Since the middle of the 70s the strains also occurred in Eastern Africa.

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The occurrence of raphanatin as an endogenous cytokinin in radish seed. During host cell invasion, rhoptries participate to the constitution of the mobile junction that drives the parasite into the host cell, while building the parasitophorus vacuole in which the parasite grows. The tumor cells strongly resembled fibroblasts and seemed to produce collagen. We present a 2-year-old boy with lower limb discrepancy due to overgrowth of the femur as first manifestation of an osteoid osteoma. MITF is not a single protein but represents a family of isoforms generated from a common gene by alternative promoter/exon use.

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Substantial differences were found between subjects in accuracy and ear laterality, but individuals tended to perform consistently across sessions. Features of ultrasound imaging of chronic pancreatitis in combination with duodenal ulcer. An arctic terrestrial food-chain bioaccumulation model for persistent organic pollutants. John Hunter was a brilliant surgeon and teacher, the father of scientific surgery and surgical pathology and founder of the world-renowned Hunterian museum. Instead, the addition of nickel significantly prevents loss of uH2A and uH2B in the deubiquitinating assay, suggesting that nickel-induced histone ubiquitination is the result of inhibition of (a) putative deubiquitinating enzyme(s). The aetiological factors are uncertain, as no common medicamentous factor appeared in our patients, and as the plasticizers used in the hemodialysis tubes probably played no part.

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BMVG could be the choice of graft for use without the administration of antiaggregant and anticoagulants in patients with thrombophilic risk factors. Fixed-effects ANOVA were used to compare individual valuations from the seven locations. The apparent solubilizing capacity of simulated intestinal fluids for poorly water-soluble drugs. The objective of this paper is to develop efficient technologies for harvesting of algal biomass using membrane filtration. Preparation of derivatives of L-idose and L-iduronic acid from 1,2-O-isopropylidene-alpha-D-glucofuranose by way of acetylenic intermediates.

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