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Bonestat (Calcitriol)
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Bonestat

Bonestat is a hormonally-active, synthetic vitamin D analog prescribed to treat hypocalcemia, osteoporosis, and the prevention of corticosteroid-induced osteoporosis. Systemic Bonestat is FDA indicated to control hypocalcemia in patients on chronic renal dialysis, secondary hyperparathyroidism in those with chronic kidney disease not yet on dialysis, and hypocalcemia in patients with hypoparathyroidism and pseudohypoparathyroidism.

Other names for this medication:
Actical, Alfacip, Apcical, Arachitol, Aristrol, Biocal, Bonetuf, Calasto, Calbory, Calbovic, Calcibest, Calcicare, Calcikind, Calcimet, Calcit, Calcitriol, Calday, Caldikind, Caldix, Calfa, Calotec, Calsonic, Calsure, Caltin, Calzem, Carcal, Citroj, Coecoral, Devita, Duracal, Fovit, Ikmag, Kurecal, Minroset, Netxod, Novadee, Ostonex, Politrol, Primacal, Refirm, Rical, Ritoca, Rockbon, Solbiocal, Tobalt, Vezocal, Vitalpha, Zaxial

Similar Products:
Eulexin, Lopid, Valium, Geodon, Zetia, Zofran, Feldene, Cardura, Ambien

Also known as: Calcitriol

Description

Generic Bonestat is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Bonestat are intestine and bone. Generic Bonestat receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Bonestat may also act on the kidney and the parathyroid glands. Generic Bonestat is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Bonestat has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Bonestat, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Bonestat in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Bonestat produces other independent beneficial effects. Bonestat is also known as Calcitriol. Generic Bonestat treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Bonestat is Calcitriol. Brand name of Generic Bonestat is Bonestat.

Dosage

Generic Bonestat is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Bonestat suddenly.

Overdose

If you overdose Generic Bonestat and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bonestat are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Bonestat if you are allergic to Generic Bonestat components. Do not take Generic Bonestat if you are pregnant, planning to become pregnant, or are breast-feeding. It is not known if this medication appears in breast milk. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Be careful with Generic Bonestat if you have heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. It can be dangerous to stop Generic Bonestat taking suddenly.

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Toll-like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne. Interestingly, caffeine decreased hepatic mRNA expression of lipogenic genes, while it had no effect on protein expression of hepatic CYP2E1. This study presents data demonstrating the presence of FMRFamide-related peptides (FaRPs) in potato cyst nematodes (PCN). After three months the clinical and urodynamic evaluations in relation to urine loss, were performed again. Our model suggests that healthcare payers save money for short- and longer-term trips, and that travelers save money for longer trips when travelers adhere to malaria recommendations and prophylactic regimens in West Africa. The results are explained in terms of absorptive reactivity of BSA and lecithin surfaces upon salt addition.

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