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Bicofen (Roxithromycin)
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Bicofen

Bicofen is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Bicofen is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring.

Other names for this medication:
Acevor, Aristomycin, Assoral, Bicofen, Biostatik, Cadithro, Claramid, Delos, Dorolid, Elrox, Erybros, Infectoroxit, Klomicina, Macrolid, Macrosil, Makrodex, Monobac, Nirox, Odonticina, Overal, Pedilid, Pedrox, Ramivan, Redotrin, Remora, Renicin, Ritosin, Rokilide, Rokithrid, Roksimin, Rolexit, Rolid, Romac, Romyk, Rotramin, Roxacine, Roxithromycin, Roxithromycine, Roxithromycinum

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Also known as: Roxithromycin

Description

Each Bicofen tablet contains either 150mg or 300mg of the active ingredient roxithromycin. Each tablet also contains: hydroxypropylcellulose, poloxamer, povidone, colloidal anhydrous silica, magnesium stearate (470), purified talc (553), maize starch, hypromellose, anhydrous glucose, titanium dioxide (171), propylene glycol (1520). Bicofen does not contain gluten, sucrose, lactose, tartrazine or any other azo dyes.

Dosage

Bicofen is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.

Overdose

If you overdose Generic Bicofen and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep the medicine in a cool, dry place where the temperature stays below 25 degrees C.

Do not store it or any other medicine in the bathroom, near a sink or on windowsill.

Do not leave it in the car. Heat and damp can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Bicofen are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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At the optic chiasm, retinal ganglion cell (RGC) axons make the decision to either avoid or traverse the midline, a maneuver that establishes the binocular pathways. The dynamics of individual colloidal particles in random potential energy landscapes was investigated experimentally and by Monte Carlo simulations. The energy distributions of common secondary ions differed somewhat in resin and two different tissue regions. Patient health issues were identified through convergence using 1) qualitative analysis of focus group transcripts and 2) quantitative analysis of the questionnaire. In addition compound 17 possesses clean CYP and hERG profiles and shows no behavioral changes in the Irwin test. Fucosylation analysis carried out for each molecular species by MS/MS permits the clear distinction between sLex and VIM-2 epitope.

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Using ultrasonography (US) multiple serous simple cysts were found in both kidneys. Loss of aldehyde dehydrogenase in an Escherichia coli mutant selected for growth on the rare sugar L-galactose. Prognostic features of ventricular tachycardia complicating acute myocardial infarction. The objective of this paper is to describe the detailed development of this simulation model for a major trauma and a rehabilitation centre in British Columbia (BC), Canada, as part of the Access to Care and Timing (ACT) project and is referred to as the BC ACT Model V1.0. Four related but conceptually and empirically distinct physical problems are described: decreased aerobic capacity, decreased muscle strength, fatigue and impaired role physical functioning. To evaluate the long term outcome after paediatric inferior vena cava (IVC) thrombosis. A spontaneously hypercholesterolemic male rat, found in the Sprague-Dawley strain, was mated with normocholesterolemic females of the same strain: the male offspring were hypercholesterolemic. The validated model is useful for counselling and pre-operative decision making. EWA was commenced at a mean age of 53 months (range 12-98 months). Abdominal adiposity seemed to play a more significant role in the development of CRFs than overall adiposity.

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A potential strategy to combat the worldwide AIDS epidemic is to develop a vaginal microbicide that prevents the sexual transmission of HIV-1. Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes. Changes in host preferences are thought to be a major source of genetic divergence between phytophagous insect taxa. The most severe human immunodeficiency virus type 1 (HIV-1) epidemic is occurring in southern Africa. The two dendrons employed are a dendron with three C(18) chains (C(18) dendron) and one with no attached hydrocarbon chains (the C(0) dendron). In the first part of this work, we describe the interaction of microglia cells with their epithelial (astrocytic) microenvironment. Coeliac disease accounts for 1 in 31 referrals in secondary care to unselected gastroenterology clinics. The results show potential for genetic improvement of indigenous Venda chickens through selection.

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Explanations for this seeming contradiction in opinions have been suggested: In individuals with straight coronoid processes, the space can narrow on opening. iMALDI permits concentration determination by affinity-capture of angiotensin I and a stable-isotopically labeled standard (SIS) peptide on immobilized anti-peptide antibodies. Erythropoietin reduces necrosis in critically ischemic myocutaneous tissue by protecting nutritive perfusion in a dose-dependent manner. Swollen rabbit corneas incubated in vitro with their posterior surfaces blocked with silicone oil maintained fairly constant thickness over an 11 hr. LPN recording from the FDI may be particularly valuable in those with global axonal loss or preferential involvement of the LPN as may occur in posterior tarsal tunnel syndrome. We discuss the genotype-phenotype correlation and the consequence of haploinsufficiency of FBN2, DTNA and CELF4 in this case. Transcription expression and clinical significance of mRNA of vascular endothelial growth factor and endostatin in liquid-based preparation specimens from patients with cervical dysplasia and carcinoma.

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Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts. Poor marrow reserve has been implicated but lacks supporting evidence as the cause of the granulocytopenia. On the other hand, tumor suppressor genes expression could be inhibited by epigenetic modifications like gene promoter hypermethylation. Consequently, tolC mutants secreted smaller amounts of the TTSS-1 effector proteins SipA and SipC, and invasion tests performed with one mutant showed that it was significantly less able to invade HT-29 epithelial cells than its parental strain. An expression is derived for the spatial power spectrum of wave-front errors after correction with a segmented mirror. Stability studies at different pH values and temperatures confirmed that the linkage of the bioactive moiety to the surface is robust and resistant to a range of pH and temperatures. Hysterographic findings in patients with repeated cesarean sections. Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study. The specific amplifications enabled nine Pythium species to be differentiated.

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The involvement of NCAM in lung tumor progression was confirmed in human NSCLC tumors. Outlet fenestration for isolated fourth ventricle with and without an internal shunt. Among these are receptor tyrosine kinases, including the epidermal growth factor receptor family B (ErbB) family receptors epidermal growth factor receptor and ErbB2. Clinical results demonstrate that SBK provides quicker visual recovery, although the data suggest that the 3- and 6-months results are similar in terms of visual outcomes. Laboratory preparation of the chemicals involved is described in detail. Lipids in neural function: modulation of behavior by oral administration of endocannabinoids found in foods.

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Cellular mechanisms control one or more of the three basic levels of regulation (transcription, translation, and protein activity/locality), allowing for finely tuned spatial and temporal regulation of protein expression patterns. Peripheral insulin resistance and hyperinsulinemia are the predominant diabetic traits in pancreatic cancer, while reduced islet cell mass and impaired insulin secretion are observed more often in chronic pancreatitis. Alterations in EP receptor expression may have the zofran medication dose potential to alter PGE(2) action. An optical heterodyne interferometer was used for measuring short ultrasonic pulses in fluids. Effects on heart rate and blood pressure as well as tachyarrhythmias have been well described. HIV-related restrictions on entry, residence and stay in the WHO European Region: a survey. We assessed the frequency of parasitic diseases and the efficacy of presumptive treatment when no cause was found. The use of a new two-in-one treatment (K Two Start) in a venous leg ulcer. Aprotinin, a bovine protease inhibitor of important therapeutic value, was expressed in tobacco plastid transformants. The effect of triiodothyronine on the disposition and actions of imipramine.

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Distributed trajectory generation for cooperative multi-arm robots via virtual force interactions. 17 -hydroxyprogesterone levels as a measure of corpus luteum function. Strong interactive effects of S (0.0, 0.2, and 0.6 g pot(-1)) and N (1, 2, and 4 g pot(-1)) supply on growth, seed yield, and the concentrations of glucosinolates and isothiocyanates in seeds were observed in growth experiments, reflecting the involvement of S-containing amino acids in both protein and glucosinolate synthesis. We used a two-step strategy: Firstly, by a competition binding assay, we identified the proper boundaries of the domain recognized by 2F5, which we found considerably larger than the ELDKWAS hexapeptide. A model is proposed wherein neutrophil elastase in mucus proteolytically cleaves the flagellar hook, thus completion of the hook basal body is never sensed, resulting in FlgM accumulation within the cell, causing repression of flagellin synthesis. Because it is absorbed transdermally, its manufacturers claim it also has a better efficacy/tolerability ratio then conventional oxybutynin. Clinically meaningful interpretation of HRQOL improvement has centered on the minimum clinically important difference (MCID). When we checked her TSH and thyroid antibodies these were elevated. We present the tool MarVis (Marker Visualization) for data mining on intensity-based profiles using one-dimensional self-organizing maps (1D-SOMs).

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