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Apalene (Adapalene)

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Apalene works well for treating mild-to-moderate acne, but it can cause burning and itching right after using it. The medication has many different formulations, but only the lower strength gel is available over-the-counter.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Zolvee

Similar Products:
Micardis, Xenical, Viramune, Depakote, Allegra, Robaxin, Decadron, Trandate, Ventolin

Also known as: Adapalene


Apalene is a third-generation topical retinoid primarily used in the treatment of acne. Apalene is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Apalene gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Apalene works under the skin surface to unclog pores and clear up pimples. Apalene is also known as Adapalene, Adapen, Adaferin. Generic name of Apalene is Adapalene.


Follow the directions for using this medicine provided by your doctor. Use Apalene exactly as directed. Apalene is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Apalene. Apalene should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Apalene. Continue using Apalene until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Apalene promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


If you overdose Apalene and you don't feel good you should visit your doctor or health care provider immediately.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Apalene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Apalene if you are allergic to Apalene components. It is not known whether Apalene will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. Do not get Apalene in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time. Do not use other medicines on your skin without first discussing it with your doctor. While you are using Apalene, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Apalene. Use a sunscreen if you must be outside. Do not apply it to sunburned skin. Do not stop taking Apalene suddenly.

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