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Alrest (Clonazepam)

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Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Alrest was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Adnil, Almac, Alrest, Anxrea, Catier, Cleps, Clonapax, Clonaxyl, Clopam, Clozep, Clozipam, Convaclon, Deptune, Dipwell, Epcon, Epizam, Escitacalm, Estalonix, Ezinite, Jbcloz, Nazee, Nexclo, Norep, Nupam, Prasilex, Repam, Somnotril, Zeptril, Zozep

Similar Products:
Levlen, Benemid, Mysoline, Flagyl, Adalat

Also known as: Clonazepam


Alrest is a benzodiazepine medication that was initially primarily used for the treatment of seizures occurring in epilepsy and for anxiety, specifically anxiety that occurs in panic disorder. Alrest is available in tablet form (0.5 mg, 1 mg, 2 mg) and as disintegrating wafers that are taken orally.

While Alrest is generally prescribed for the treatment of anxiety disorders, such as panic disorder, and seizure control, it is intended as a short-term treatment protocol as opposed to a long-term treatment solution due to issues with tolerance (see below). In addition to treating anxiety and seizures, Alrest has also been used in the treatment of:

chizophrenia, especially when the individual with schizophrenia has a restless or irritable component and is not responding to antipsychotic medications.

The manic phase of bipolar disorder or for restlessness associated with depression in bipolar disorder.

Tic disorders, such as Tourette's syndrome, by acting as a muscle relaxant and producing sedation.

Restless leg syndrome.

Withdrawal from alcohol or treatment for other substance abuse or addiction issues.

Alrest has a relatively slow onset of action (it takes a while for the drug to begin working) and a half-life of between 10 and 50 hours. As it has a relatively slow onset of action and is a longer-acting benzodiazepine, Alrest is more suited for the treatment of anxiety, seizures, and other similar disorders as opposed to being a useful sleep aid, even though it is sometimes prescribed for that purpose. Sleep aids need to work quickly, whereas with Alrest, a person takes the drug early in the day and doesn't have to worry about monitoring for signs of a seizure or panic attack as it stays in the system a relatively long time. Its effects last longer than those of shorter-acting benzodiazepines, such as Xanax.

As it is a Schedule IV controlled substance, Alrest can only be legally acquired with a prescription from a physician.


Alrest is also used to treat symptoms of akathisia (restlessness and a need for constant movement) that may occur as a side effect of treatment with antipsychotic medications (medications for mental illness) and to treat acute catatonic reactions (state in which a person does not move or speak at all or moves or speaks abnormally). Talk to your doctor about the possible risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Alrest.

Do not let anyone else take your medication. Alrest is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


Benzodiazepines like Alrest became popular prescription medications, as alternatives to another class of anti-anxiety medications called barbiturates. Barbiturates were once very popular in the treatment of anxiety; however, they were highly addictive, carried a high risk for overdose, and were frequently abused. Benzodiazepines also carry a significant risk for the development of physical dependence and abuse (see below); however, they do not appear to carry the same risk of overdose that is associated with barbiturates (although overdose on benzodiazepines can occur).

Many of the cases of overdose that include benzodiazepines also include the co-occurring use of other drugs, such as alcohol, narcotic pain medications, or antidepressants. Using these drugs and benzodiazepines like Alrest together enhances the effects of all drugs as well as increases the risk for overdose and potential fatalities due to drug interactions and drug overdose.


Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Alrest are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Alrest may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Tell your doctor if you are taking or plan to take certain opiate medications for cough such as codeine (in Triacin-C, in Tuzistra XR) or hydrocodone (in Anexsia, in Norco, in Zyfrel) or for pain such as codeine (in Fiorinal), fentanyl (Actiq, Duragesic, Subsys, others), hydromorphone (Dilaudid, Exalgo), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Astramorph, Duramorph PF, Kadian), oxycodone (in Oxycet, in Percocet, in Roxicet, others), and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take Alrest with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

Drinking alcohol or using street drugs during your treatment with Alrest also increases the risk that you will experience these serious, life-threatening side effects. Do not drink alcohol or use street drugs during your treatment.

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standard control of SBP is associated with greater reduction of cardiovascular risk is unclear. A total of 1415 Uygur residents aged 18 and over were selected by random multistage and probability proportional to size from 364 villages in Moyu county of Xinjiang Uygur autonomous region, all subjects received questionnaire, physical examination and biochemical analysis and oral examination. Temporal unpredictability of a stimulus sequence and the processing of neutral and emotional stimuli. This indicates that the Hsp60 protein is a common constituent of the biofilm produced by H. The results showed that the stresses on the cancellous bone beneath a conventional-design prosthesis may be lowered if a metal tray and metal peg are employed. Various cytokeratins and markers of lymphoma, melanoma, germ cell tumours and primary CNS tumours were negative. This study is the first report of dental abnormalities in Brazilian patients with FS. -- In the paralel group with differences in the non-H-1 systems of BP into BN-1B, destroyed after 30 days, there were -- in addition to moderate acute rejection -- hypercellular glomerules with electrodense deposits in the mesangium seen as a manifestation of immuno-complex glomerulonephritis.

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The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. The authors have designed high-throughput screens to identify compounds that promote or inhibit terminal differentiation of primary human epidermal keratinocytes. PFC concentrations in blood plasma of children and adults exposed to PFC-contaminated drinking water were increased 4- to 8-fold compared with controls. However, there remains a glaring mismatch between where studies on physical activity interventions are undertaken and where the potential lies in low-income and middle-income countries for population-level effects that will truly affect global health. We investigated whether and how perceived social support is associated with depression and quality of life among patients with various cancer diagnoses. We also sought to confirm whether the presence of a fistula further reduced AT. Millimeter wave stimulation was found to significantly enhance chondrocyte viability. Immunohistochemistry of Ki-67 protein is widely used to assess tumour proliferation, and is an established prognostic factor in breast cancer. We sought to characterize the relationship between smoking status and distant metastasis. The synergy index (SI) was recorded or calculated, whenever possible.

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Using quantitative genetic theory, we develop predictions for the evolution of trade-offs in response to directional and correlational selection. Five hundred and seventeen patients with early UA, included in the Leiden Early Arthritis Clinic, were assessed. We report a case of cutaneous SCC which was diagnosed by the presence of bone metastasis and treated with combination chemotherapy. Detailed protocols for fetal calf serum selection and other culture parameters that affect the final outcome are described. ALE results indicated several regional task-based BOLD consistencies in MCI and AD patients relative to normal control subjects across the aggregate BOLD functional neuroimaging research literature. In this paper, the material and spatial characterization of the flows cyproheptadine dose adult within a municipal solid waste (MSW) management system are combined through a Network-Based Spatial Material Flow Analysis.

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Explorations into CB expansion and multiple CB unit transplants are addressing the limited cell doses attainable with a single CB collection. This small peptide inhibitor induces a decrease in HIV-1 viral valium pill finder transcription in vitro and minimizes viral loads in vivo. However, out of position considerations have to be taken into account in the development of pretension systems. Malignant tumors of the head and neck in children: diagnosis and treatment. Combination therapy for pulmonary artery hypertension: what is the evidence?. The number of necessary days of hospitalization was reduced by 45, as compared with a previous intensive outpatient program for pregnant diabetic women without self-monitoring. Palliative chemotherapy and the epidermal growth factor receptor inhibitor, cetuximab, constitute the backbone of treatment for patients with R/M HNSCC.

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