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This study was conducted to establish the maximum tolerated dose (MTD) of intravenous vinorelbine and on the determined dose to assess efficacy and safety in patients with metastatic breast cancer previously treated with epirubicin. Appropriate drug prescription, either in terms of drug choice or in terms of drug dosage, is of paramount importance among the frail elderly patients, this requiring the need of a difficult balance between efficacy, safety and tolerability. Graphene-quantum-dot assembled nanotubes: a new platform for efficient Raman enhancement. Thirty physical therapists, occupational therapists, and sports therapists from 10 Dutch and Flemish SCI centers. Ziehl-Neelsen staining showed acid-fast bacilli of Mycobacterium tuberculosis. Together, our observations argue that ligand endocytosis is critical for Notch signaling and auxilin participates in Notch signaling by facilitating ligand internalization. A total of 14 genetic variants including 3 novel single-nucleotide polymorphisms (SNPs) in the ORAI1 gene were identified.
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