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Alfacalcirol (Calcitriol)
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Alfacalcirol

Alfacalcirol is a synthetic version of Vitamin D3 used to treat calcium deficiency with hypoparathyroidism (decreased functioning of the parathyroid glands) and metabolic bone disease in people with chronic kidney failure.

Other names for this medication:
Alcee, Alfacal, Alfacalcirol, Apcical, Aristrol, Bonestat, Calcibest, Calcikind, Calcit, Calcitriol, Calcor, Caldix, Calfa, Calsure, Calzem, Carcal, Cholical, Citroj, Coecoral, Denscal, Dmcal, Fovit, Ikmag, Minroset, Osteobel, Politrol, Qpcal, Rical, Riecal, Roical, Septriol, Solbiocal, Sunmic, Tobalt, Vezocal, Vitalpha

Similar Products:
Loxitane, Ovral, Avapro, Ceftin, Ultram, Danocrine

Also known as: Calcitriol

Description

Generic Alfacalcirol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacalcirol are intestine and bone. Generic Alfacalcirol receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacalcirol may also act on the kidney and the parathyroid glands. Generic Alfacalcirol is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacalcirol has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacalcirol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacalcirol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacalcirol produces other independent beneficial effects. Alfacalcirol is also known as Calcitriol. Generic Alfacalcirol treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacalcirol is Calcitriol. Brand name of Generic Alfacalcirol is Alfacalcirol.

Dosage

Generic Alfacalcirol is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Alfacalcirol suddenly.

Overdose

If you overdose Generic Alfacalcirol and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alfacalcirol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Alfacalcirol if you are allergic to Generic Alfacalcirol components. Do not take Generic Alfacalcirol if you are pregnant, planning to become pregnant, or are breast-feeding. It is not known if this medication appears in breast milk. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Be careful with Generic Alfacalcirol if you have heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. It can be dangerous to stop Generic Alfacalcirol taking suddenly.

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To get additional insights into the role of beta-catenin in the regulation of the cell cycle and apoptosis, we have analyzed the levels and subcellular localization of endogenous beta-catenin and its relation with adenomatous polyposis coli (APC) during the cell cycle in S-phase-synchronized epithelial cells. Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue. Examination of artificial MiRNA mimics with centered-site complementarity for gene targeting. Inhalation therapy of diethylene-triamine-penta-acetate (DTPA) should be initiated immediately to workers who have significant incorporation of plutonium, americium or curium in the nuclear fuel reprocessing plant. Whether personality represents a predictor or an outcome of social circumstances needs further research. Historically, in vitro angiogenesis assays study individual aspects of the process and tend to be variable, difficult to quantify, and limited in clinical relevance. The aim of our study was to determine the Se concentration in human milk and to calculate the daily Se intake by breast-fed infants in western Poland. EFRS patients who demonstrate an allergic response to the fungi are diagnosed as having AFRS and those who cannot demonstrate any allergic responses to the fungi are diagnosed as having non-allergic fungal rhinosinusitis (NAFRS). Fruit size as a model for teaching first trimester uterine sizing in bimanual examination. Experimental variables included transmission quantity, probe frequency, direction of pressure change, and type of probe tip.

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Cochlear implantation with all three Food and Drug Administration-approved devices. Deuterium lamp as a UV continuum source from 160 nm to 320 nm for space applications. Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression. Particle beam glow discharge mass spectrometry: spectral characteristics of nucleobases. To evaluate the significance of nuclear morphometry in predicting the clinical course in superficial (pTa and pT1) bladder cancer.

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Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists. The use of antibiotics was significantly lower in the group managed according to the BPS compared to the conventionally treated group, without increasing the rate of treatment failure. Generally the disease presents acutely with fever, pneumonitis and hepatitis. Chest radiograph revealed a fungus ball within a left lower lobe cavity. We produced a pair of coherent laser beams with a 3-GHz frequency difference by optically phase locking two modes from a single, multimode extended-cavity diode laser.

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Generation of transgenic zebrafish expressing green fluorescent protein under control of zebrafish amyloid precursor protein gene regulatory elements. Neither differentiation of myxomas cells up to mature endotheliocytes no signs of malignant transformation was found. Following squalene feeding, BP and body weight gain were lower in the squalene group. In this paper we characterize the binding of 5alpha-substituted swainsonine analogues to the soluble catalytic domain of Drosophila GMII by X-ray crystallography. Implications of these findings for public health policy issues were discussed. Pharmacists participated in semi-structured telephone interviews to discuss their prescribing practices and explore the facilitators and barriers to implementation. Heme oxygenase-1 activity was also increased in the lung tissues after ATL stimulation.

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We evaluated dengue case definitions in a prospective study at a pediatric hospital in Bangkok, Thailand, during 1994-2005. In a second questionnaire the women were asked to record pain in the 3 days following insertion and both pain and bleeding from 4 to 6 weeks after insertion. This study demonstrates the importance of taking a long-term overview of the cost versus benefits of adjunctive psychological therapy in bipolar disorders. The classically conditioned eyeblink reflex is the best studied model for understanding the neural mechanisms that underlie learning and memory. The potential importance of phenologically-driven changes in soil resource acquisition for plant fitness and productivity flonase prescription dose have received little attention. Bronchial fibrolipomatous hamartoma associated with peculiar unusual bronchial lesions of the peripheral lung. ART2.2 on T cells may not simply mark the resting state, but could also contribute to it via ADP-ribosylation. Frequency of detection the of Brugada syndrome signs in the course of ECG registration. In a hypothetical group of 1000 individuals, routine use of iv PPI prevented 40 rebleeds, 9 surgical procedures, and 223 hospital days, and led to incremental savings of dollars 920 per subject. Both 2D and 3D-RA contributed equally to the therapeutic intervention in 4 (4/12) patients.

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Possible undetected outbreaks of cryptosporidiosis in areas of the north west of England supplied by an unfiltered surface water source. With the availability of indium-labeled white blood cells, radionuclide imaging studies have a definite role in the diagnosis and staging of patients with inflammatory bowel disease. Children with symptoms of bilateral tonsillar hyperplasia underwent laser tonsillotomy. The sensors measure substrate coupling capacitances of cells cultured on-chip in a standard in vitro environment. In order to test this assumption, a sensitive analytical method that can differentiate 9-cis, 13-cis, and all-trans RA in small tissue samples ( approximately 8 mg) is required. Degradation studies on ouabain provided an ultimate proof for a key intermediate, which is used as a relay. We characterized these expenses in patients seeking fertility care. High-performance liquid chromatographic determination of Fluazifop-butyl and Fluazifop in soil and water. The hypothesis for this study is that there are factors generated during the development of chronic lung disease that increase AP-1 DNA binding activity and Ref-1 production in human alveolar macrophages. Our approach adopts a split probe targeting system, designed with G-rich sequences, which reassembles in the presence of target DNA, producing G-quadruplexes with catalytic activity.

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Minimally invasive surgery to treat severe acromioclavicular dislocation combined with coracoid process fracture. In healthy, untreated leeches, botryoidal cells are organized in cords or clusters, sometimes surrounding few, small lacunae. To investigate the psychometric properties of the BMSLSS-College among 723 college students. The T159D mutation, surprisingly, severely diminishes phosphatase activity, apparently by disturbing the active site scaffold: Arg-191 is swung out of the active site resulting in conformational changes in His-158 and His-197 residues. The attractiveness of this species as an animal model is based on two important facts.

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