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Acuzole (Metronidazole)
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Acuzole

Acuzole is a medicine used to treat different types of bacterial and parasitic infections, including those that affect the skin, vagina, blood, heart, bone, stomach, liver, joints, nervous system, respiratory tract, and other areas of the body.

Other names for this medication:
Acuzole, Aminidazole, Amobin, Amotein, Amrizole, Anaerobex, Birodogyl, Collazole, Corsagyl, Diazole, Etronil, Flanizol, Flazole, Fortagyl, Gnostol, Gynoplix, Kilpro, Klion, Litagyl, Mecozol, Metazole, Metren, Metrin, Metris, Metrodal, Metrogel, Metrolyl, Metronidazol, Metronidazols, Metronide, Metrozin, Metrozole, Micogyl, Minegyl, Molazol, Nidazole, Nipazol, Otrozol, Patryl, Repligen, Rosasol, Rosiced, Suanatem, Tismazol, Trichostatic, Vagilen, Vagizol, Vandazole, Varizil, Vertisal

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Also known as: Metronidazole

Description

Acuzole (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Acuzole is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

The dosage regimen should be individualized. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to con- tinue the seven-day regimen. A seven-day course of treatment may minimize reinfection by pro- tecting the patient long enough for the sexual con- tacts to obtain appropriate treatment. Further, some patients may tolerate one treatment regi- men better than the other.

Overdose

In cases of overdose in adults, the clinical symptoms are usually limited to nausea, vomiting, ataxia and slight disorientation. In a preterm newborn, no clinical or biological sign of toxicity developed.

There is no specific treatment for Acuzole overdose, Acuzole infusion should be discontinued. Patients should be treated symptomatically.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Side effects

The most common side effects associated with Acuzole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

As a rule, the usual duration of therapy with i.v Metronidazole or other imidazole derivatives is usually less than 10 days. This period may only be exceeded in individual cases after a very strict benefit-risk assessment. Only in the rarest possible case should the treatment be repeated. Limiting the duration of treatment is necessary because damage to human germ cells cannot be excluded.

Intensive or prolonged Metronidazole therapy should be conducted only under conditions of close surveillance for clinical and biological effects and under specialist direction. If prolonged therapy is required, the physician should bear in mind the possibility of peripheral neuropathy or leucopenia. Both effects are usually reversible.

In case of prolonged treatment, occurrence of undesirable effects such as paraesthesia, ataxia, dizziness and convulsive crises should be checked. High dose regimes have been associated with transient epileptiform seizures.

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Embryonic zebrafish neuronal growth is not affected by an applied electric field in vitro. The amplification of microsatellite markers in less stringent amplification conditions resulted in a distinct electrophoretic profile for species within section Fumigati. It is proposed that the bacterial-produced EPS was a key factor to mediate bacterial attachment to other surfaces and develop biofilms, thereby increasing the bioavailability of poorly soluble PAH for enhanced biodegradation. Being involved in a compensation process is associated with higher mental health complaints but three-quarters of the difference appeared to be already present at baseline. Techniques and early results of treatment of carcinoma of the larynx and pharynx by supervoltage radiation.

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