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Actos (Pioglitazone)

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Actos is a diabetes drug (thiazolidinedione-type, also called "glitazones") used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. It works by helping to restore your body's proper response to insulin, thereby lowering your blood sugar.

Other names for this medication:
Accuglim, Amaryl, Asoride, Dibiglim, Geoglit, Glime, Glimestar, Glimiprime, Glimsite, Glizone, Glyciphase, Matce, Mefomin, Mepride, Nodiab, Pglit, Piodart, Pioglu, Piolet, Piozed, Piozol, Piozulin, Tgmet, Triglimiprex, Triglycomet, Ziglim, Zogli

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Also known as: Pioglitazone


Actos is an effective drug of the class thiazolidinedione (TZD) with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes mellitus type 2. Actos contains the active ingredient Pioglitazone Hydrochloride. Pioglitazone helps to lower blood glucose levels by increasing the sensitivity of liver, fat, and muscle cells to insulin; enables cells to remove glucose from the blood more effectively, reduces the amount of glucose produced by the liver, and preserves the functioning of the cells in the pancreas that produce insulin. Actos does not cause the body to make more insulin. Therefore, when used alone, it does not cause low blood glucose (hypoglycemia). Actos is used either alone or in combination with other anti-diabetic medications (such as insulin, metformin, or a sulfonylurea such as glyburide). Actos is not taken to treat type 1 diabetes.


Take Actos by mouth with a full glass of water with or without food. The initial dose of Actos is 15 mg once a day. In case of inadequate glycemic control, the dose can be increased up to 45 mg once daily. If hypoglycemia occurs in a patient co-administering Actos and insulin, the dose of insulin should be decreased by 10% to 25%. Further adjustments to the insulin dose should be individualized based on glycemic response. Take the drug at the same time each day. If you want to achieve the most effective results, do not stop taking Actos suddenly.


If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your health care provider immediately. You can experience the following symptoms of Actos overdose: signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actos are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Actos can interact with several other medications. It’s not known to interact with supplements or foods.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase the number of side effects or make them more severe.

Actos and other medications

Below is a list of medications that can interact with Actos. This list doesn’t contain all drugs that may interact with Actos.

Before taking Actos, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

Actos and other diabetes medications

Sometimes your doctor may prescribe Actos along with other medications for your type 2 diabetes, such as glyburide (DiaBeta) or insulin. However, this may put you at risk for developing hypoglycemia (low blood sugar).

Hypoglycemia can cause symptoms such as dizziness, sweating, and headache. In severe cases, you may have serious complications such as a seizure or passing out.

Before starting Actos treatment, it’s important to tell your doctor what other medications you’re taking.

You should also talk with your doctor about what to do if you develop symptoms of hypoglycemia, especially if you’re taking multiple diabetes medications.

Actos and gemfibrozil

Gemfibrozil (Lopid) may interact with Actos. If you’re taking gemfibrozil, the level of Actos in your body will rise. Gemfibrozil can also increase the amount of time that Actos stays in your body.

If there’s too much Actos in your body and you’re also taking other diabetes medications such as insulin, your blood sugar can get too low. This can cause symptoms such as dizziness or sweating.

Before you start taking Actos, have your doctor review your all medications. They can adjust your treatment as needed.

Actos and rifampin

Taking rifampin (Rimactane) along with Actos may decrease the level of Actos in your body. This means that you may not get enough Actos, and it may not work to treat your type 2 diabetes.

If you start or stop taking rifampin while using Actos, your doctor may need to change your dose of Actos.

Actos and topiramate

If you take Actos along with topiramate (Topamax, Trokendi XR, Qudexy XR), the level of Actos in your body may decrease. This means that the Actos may not work well to treat your type 2 diabetes.

If you’re taking topiramate and Actos, talk with your doctor. They may recommend changing your dose of Actos or monitoring your blood glucose more often to be sure that Actos is working for you.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Actos and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Actos. However, you should still check with your doctor or pharmacist before using any of these products while taking Actos.

Actos and foods

There aren’t any foods that have been specifically reported to interact with Actos. If you have any questions about eating certain foods with Actos, talk with your doctor.

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Moreover, it is advisable that strict measures be put in place to check the increasing microbial load in the hospital environment. The results showed that the women were poorly informed before delivery about pregnancy-related complications and medical indications for emergency care. Gefitinib efficacy associated with multiple expression of HER family in non-small cell lung cancer. The risk of hypotension is associated with the last dosage rate of maternal ketanserin treatment and the co-existence of maternal HELLP syndrome. Mixed poly (ethylene glycol) and oligo (ethylene glycol) layers on gold as nonfouling surfaces created by backfilling. Influenza A virus-induced polymorphonuclear leukocyte dysfunction. The present study addressed discrimination of speech prosody in children with AS at neurophysiological level. Eight patients with chronic severe asthma, poorly controlled by conventional doses of inhaled bronchodilator, were treated with high-dose inhaled terbutaline (4 mg four times daily), via either wet nebulisation of terbutaline respirator solution, or by tube-spacer aerosol, using cannisters delivering 1 mg terbutaline per metered dose. Effects of potential probiotic Bacillus subtilis T13 on growth, immunity and disease resistance against Vibrio splendidus infection in juvenile sea cucumber Apostichopus japonicus.

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198 out of 310 Pleconaril variants analyzed for docking with NA active site were proven effective, based on their free binding energy. Although the precise culprit in the etiopathogenesis of Alzheimer disease (AD) is still obscure, defective mitochondria functioning has been proposed to be an upstream event in AD. Portal vein thrombosis (PVT) is a rare cause of abdominal pain, typically associated with cirrhosis or thrombophilia. Further research on the financial implications of self-castration from different health care systems and from a series of patients is needed. Association of acculturation levels and prevalence of diabetes in the multi-ethnic study of atherosclerosis (MESA). The transport of anions across cellular membranes is an important biological function governed by specialised proteins. Whole-genome expression analysis of Rice black-streaked dwarf virus in different plant hosts and small brown planthopper.

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After 24-month follow-up, the patient was well, had no bleeding tendency, and had mild chronic skin graft-versus-host disease. Forty residents, 6 cardiology fellows, and 4 experienced physicians participated. As a group, the glycosaminoglycans provide mechanical strength to skin, as they can absorb water and occupy the space between elastin fibers and collagen. Despite the strong interest in health care quality, little is known about the quality of preventive care among women in rural primary care settings. The tight regulation of these genes is crucial for reprogramming, but the mechanisms that regulate their expression in vivo have not been uncovered. How to tailor treatment based on these newer prognostic factors remains a central, as yet unanswered management question. Light and desiccation responses of some Hymenophyllaceae (filmy ferns) from Trinidad, Venezuela and New Zealand: poikilohydry in a light-limited but low evaporation ecological niche. Astrocytes were revealed immunocytochemically by using antibodies to GFAP, vimentin and nestin. After confirmation of the expression intensity using an in-house manufactured DNA array with cDNAs from the DA graft, 36 genes were classified in the highly expressed group and 26 moderately expressed group. The increase in SPR line width, the decrease in the resonance field and also increase in anisotropy filed by decreasing the temperature core-shell type structure of the nanoparticles and disordered magnetic structure (spin-glass like phase) of the particle surface.

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How GPs negotiate patient requests is vital to their gatekeeper role but also a source of potential conflict, practitioner stress and patient dissatisfaction. Horses under sevoflurane anesthesia may require less pharmacological support in the form of dobutamine than isoflurane-anesthetized horses. The determination of IL-6 in seminal plasma and postmasturbation urine samples is useful as an addition to the diagnostic test for the patient with CP/CPPS and as an efficacy marker for therapy. Proton magnetic resonance spectroscopic imaging (1H-MRSI) examinations were performed in 10 patients with TBI 48-72 h after the trauma, to obtain early measurements of central brain levels of N-acetylaspartate (NAA), choline (Cho), creatine (Cr) and lactate (La). Since the indiscriminate destruction of these communities to control zoonoses is highly undesirable, the epidemiological role of the animals must be properly assessed in order that alternative methods of control can be developed. Furthermore, the results of protoplast transient assays in vivo and electrophoretic mobility shift assays in vitro have revealed that EIN3 can bind and activate the EBF2 promoter, indicating that EIN3 modulates EBF2 gene expression in planta. A case of a superficial carcinoma of the esophagus with isolated lymph node metastasis around the abdominal aorta. Fifty-five WDLS and 52 DDLS were analyzed using Agilent 244K comparative genomic hybridization and Affymetrix U133A expression arrays. Efficacy and safety characteristics of mometasone furoate/formoterol fumarate fixed-dose combination in subjects with moderate to very severe COPD: findings from pooled analysis of two randomized, 52-week placebo-controlled trials. Prognostic factors responsible for pain relief and cement leakage were examined using meta-regression.

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Environmental cues are transmitted to the interior of the cell via a complex network of signaling hubs. Serum samples and skin biopsy specimens were collected from 15 patients at the time of diagnosis and after the end of treatment with psoralen plus ultraviolet A/interferon alfa-2b combination therapy. Increased expression of matrix metalloproteinase-13 in glioma is associated with poor overall survival of patients. Studies on the concept of psychosocial adaptation related to the concept of social competency allow to propose a link between the level of social adaptation and this trait of personality that is the focus of control. Yeast-secreted Bbs can be used reliably in cost-effective yet highly sensitive bead-based assays for use in large validation studies. The recent findings from our laboratory and others discussed in the present review outline pleiotropic roles for miR-192 in renal homoeostasis and in the fibrotic kidney. To choose the optimum initial processing methods of Rheum palmatum.

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All patients were aged between 18 months and 69 years, and 49 were paediatric cases. Offspring birth weight and cardiovascular risk in parents: a population-based HUNT 2 study. Both uric acid and endothelial dysfunction are associated with new occurrence of type-2 diabetes but, at this moment, there is no evidence about a possible interaction between them. To investigate the correlation between image noise and body mass index (BMI) in multislice CT angiography (MSCT) for patients with abdominal aortic aneurysm (AAA) treated with endovascular stent grafts. The present paper gives the results of a comparative study on the drimane-type sesquiterpenoids in some liverworts, ferns and higher plants, and the role of tocopherols in these plant groups.

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We report three cases of neonatal renal failure, including a pair of twins, following ingestion of diclofenac by the mother during pregnancy. Identifying gastroduodenal uptake of (99m)Tc-macroaggregated albumin (MAA), which is associated with an increased risk of ulcer disease, is a crucial part of the therapeutic management of patients undergoing radioembolization for liver tumours. Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo. The association between malignancy and chromoblastomycosis is very uncommon, but medical staff who deal with this disease should be attentive to this possibility, as early detection of these neoplasms will provide an adequate treatment, improving survival and quality of life for those patients. Our patient received non-standard dose-escalation for piperacillin-tazobactam. Cases showing basophilic inclusions reported so far have been divided into two groups: early onset FTD and MND with basophilic inclusions. Lung/chest expansion contributes to generation of pleasantness associated with dyspnoea relief.

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A synthetic EGF-like (EGFL) peptide (DdEGFL1), equivalent to the first EGFL domain in the extracellular matrix protein CyrA, has previously been shown to enhance random cell motility and cAMP-mediated chemotaxis in Dictyostelium discoideum. When used as part of the whole treatment regimen, these devices will aid in decreasing pain, inflammation, and contracture formation, and aid in improving flexibility, range of motion, and, most importantly, healing time and full return to performance. Importantly, we confirm that SKI-1/S1P is a key host factor for HCV infection by using a specific active, site-directed, small-molecule inhibitor of SKI-1/S1P: PF-429242. Describe the clinical characteristics, treatment and prognosis of hospitalized patients admitted with acute HF. Direct comparison was made with CC (performed later the same day). SGAG-binding receptors recognize anionic structural motifs within extended SGAG chains. Curcumin sensitizes chemotherapeutic drugs via modulation of PKC, telomerase, NF-kappaB and HDAC in breast cancer. At the end of four weeks, serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C), and markers of oxidative stress viz., malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in the serum and liver of HCD and normal rats were assessed and compared. On the problem of the identity of hemolyzing saprophytic Neisseria. The incidence of dermatomycoses in East Mecklenburg with special reference to the flora of epidermo-phytosis in the years 1958/59.

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Structure-activity relations between alkyl nucleophilic chemicals causing duodenal ulcer and adrenocortical necrosis. The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation. Supplementation of exogenous antioxidants or boosting endogenous antioxidant defenses of the body is a promising way of combating the undesirable effects of reactive oxygen species (ROS) induced oxidative damage. It is suggested that the infant mortality problem in the U.S.S.R. Dogs received 3 induction regimens in a randomized crossover study. Cell culture demonstrated that HBSM readily migrated into and initiated remodelling of the electrospun fibrinogen scaffolds by deposition of collagen. It was also noted that there was no correlation between Se in hair and serum of the same individuals.

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Twenty-one Wistar rats were randomized to a control group or to receive intraperitoneal EPO (500 units per kg) once a day for 5 days starting 45 min (EPO45min) or 6 h (EPO6h) after burn injury. To identify and investigate novel regulators that modulate cardiac hypertrophy. Based on these findings, the fear of their child developing atopic disease should not deter parents from immunising their children, especially when weighed against the benefits. Tear IgA-ELISA: a novel and sensitive method for diagnosis of ophthalmic cysticercosis. Microwave Accelerated Green Synthesis of Stable Silver Nanoparticles with Eucalyptus globulus Leaf Extract and Their Antibacterial and Antibiofilm Activity on Clinical Isolates. An update on the diagnosis and management of dementing conditions. Clinical manifestations and treatment outcomes in this setting were comparable to that of the MSF programmeme in Tigray, Ethiopia and highlight the importance of HIV testing for patients presenting with visceral leishmaniasis. This article outlines the available options and recent advances in the treatment of hearing impairment. Malic enzyme from Kalanchoe crenata: effects of carbon dioxide concentration. Notes on Bonea Roewer, 1914 and Lomanius Roewer, 1923 (Opiliones: Laniatores: Podoctidae), with the description of three new species from China.

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Exploitation of cyclopropane ring-cleavage reactions for the rapid assembly of tetracyclic frameworks related to gibberellins. aeruginosa, while As(III) at concentrations ranging from 0 to 1 mg L(-1) showed no significant inhibition. Causes for loss of teeth among cases visiting Government General Hospital (Dental Department) Madras. This synergy was also noted when the closely related compound ABT-737 was combined with the same immunotoxin. Two city maternity units in southwest England and Eastern Scotland. Increase of radiation damage to potassium-ion permeability in E. We detected no significant differences in the distribution of any of the tested alleles, genotypes or haplotypes between the investigated groups. The nursing contribution to pain treatment must be acknowledged within initiatives to improve pain management. A two component system of pure gold and an alloy of silver, copper, palladium and zinc has been shown to have similar mechanical properties to those of Type C casting golds. In these patients, testosterone replacement therapy does not seem to worsen lower urinary tract symptoms.

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This paper provides a comparison of several blind source separation (BSS) techniques as they are applied to EEG signals. Xenopus laevis larval thymocytes do not express surface immunoglobulin. The authors observed three cases of exogenous lipid pneumonia clinically suspected of lung carcinoma. These observations warrant urgent intervention and threaten the success of treatment programmes for tuberculosis and HIV. Most patients with acute or chronic renal disease exhibit some degree of neurologic dysfunction affecting the CNS, peripheral nervous system, or both. We found that some tumors, such as M1801, appeared to be mixtures of cells that varied in their expression of 3.1. The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. Achieving team consensus on best practice rehabilitation guidelines following primary total hip replacement (THR can you drink alcohol when taking diamox ) surgery. In summary, the use of (68)Ga-DOTATATE PET/ceCT leads to an increase in sensitivity and specificity in the detection of extra-hepatic NET metastases compared to stand-alone ceCT.

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We found that subsong production in zebra finches does not require HVC (high vocal center), a key premotor area for singing in adult birds, but does require LMAN (lateral magnocellular nucleus of the enalapril maleate drug card nidopallium), a forebrain nucleus involved in learning but not in adult singing. CA15.3 (also known as MUCI) is the most widely used marker in breast cancer. Specifically, it was useful to detect defecation-related problems, sexual dysfunction and a mismatch in judging the importance of psychological distress between patients and their doctors. Topographic anatomy of the supradiaphragmatic part of the thoracic duct in dogs (preliminary report). A total of 7 studies met all criteria and were included in the final analysis. Nonspecific acid alpha naphthyl acetate esterase (ANAE) activity has been demonstrated in bovine lymphocytes and monocytes-macrophages. This retrospective study was possibly underpowered, given the small sample sizes. Each country had a unique mix of enablers and barriers to reclassification.

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It is apparent that the membranes of endoplasmic reticulum or Golgi apparatus are not directly involved in autophagic vacuole formation. 17beta-HSD 2 has been studied only in mammals, its occurrence and function in other vertebrates hardly known. Our measurements reveal that minimalistic reconstituted cytoskeletal networks (F-actin/HMM) exhibit a similarly peculiar response. The binding of nuclear factors to the as-1 element in the CaMV 35S promoter is affected by cytosine methylation in vitro. Those funded through global budgets and other decentralized budget modalities perform on a par with private providers funded mainly by private prepaid health plans. We introduce a model of episodic memory retrieval that characterizes contributions of posterior parietal cortex. Antibiotics remain an expensive option and misuse of these agents results in significant antibiotic resistance and contributes to escalating health care costs. The possible role of plasma insulin levels as a risk factor of coronary heart disease has been studied in a population of 7246 non diabetic, working men, aged 43-54 years, initially free from heart disease, and followed for 63 months on average.

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Peroxide changes the redox state of the enzyme and renders it highly stable against attack by alkylating agents. In this study, the microbiological quality of fresh rainwater was assessed from 50 rain events under tropical weather conditions for a year. Trp207Gly in platelet glycoprotein Ibalpha is a novel mutation that disrupts the connection between the leucine-rich repeat domain and the disulfide loop structure and causes Bernard-Soulier syndrome. Uveitis in childhood is a vision-threatening group of inflammatory disorders arising from numerous etiologies that vary geographically and historically. The important criteria for designing future pharmacologic studies are discussed. Sparing and judicious use of steroids needs to be borne in mind in treatment of ARDS and acute hepatitis from alcohol or autoimmune process. Response of renin, aldosterone and antidiuretic hormone to furosemide and furosemide-triamterene combination. However, diagnostic characters are recovered from the parts preserved, including the skull, partial forelimbs (including the left hand), legs, and distal portions of both feet.

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Normal-incidence silicon-gadolinium multilayers for imaging at 63 what does generic prilosec look like nm wavelength. Mathematical investigation of populations of coupled synthesized relaxation oscillators representing biological rhythms. Overall, concurrent application of SAHA and Cddp yielded the most favorable cell kill, indicating that this combination is promising for treatment of platinum-resistant ovarian tumors. Both Zeb1 and Zeb2 were expressed at mesenchyme of the palate, hair follicle, and tooth germ throughout the stages. The aim of this study was to investigate this potential association. Nitrate is a widespread contaminant of drinking water supplies, especially in agricultural areas. Examples of the tests best illustrating the classical neuropsychological protocol are presented.

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Shrinkage of the kidney, a common sequela, also may be detected at CT. Murine embryonic blood between day 10 and 13 of gestation as a source of immature precursor B cells. In our work, we have assessed the efficacy of two different plant defence activators, menadione sodium bisulphite (MSB) and 1,2,3-benzothiadiazole-7-thiocarboxylic acid S-methyl ester (BTH), as inducers of resistance mechanisms of the model plant for defence, Solanum lycopersicum, against the generalist mollusc Theba grasseti (Helicidae). Short oxygen prebreathing and intravenous perfluorocarbon emulsion reduces morbidity and mortality in a swine saturation model of decompression sickness. Re: physician documentation of fluoroscopy time in voiding cystourethrography reports correlates with lower fluoroscopy times: a surrogate marker of patient radiation exposure. One of its elements is the dermal basement membrane that provides a link between the epidermis and the dermis. In a context of widespread vaccination and rational use of ventolin generic names antibiotics, innovative antibiotic, prescribed to all age groups, may have an added impact on multiresistant-strain dissemination in the population. Two populations were genotyped with different marker sets at different density: IBM Syn4 and IBM Syn10. miR-122, a short noncoding RNA, has been shown to mediate the up-regulation of LRBP. The bisphosphonates have established fracture efficacy to 3 years, and 4 or 5 years with alendronate and risedronate.

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Virtual slides of atypical cells in cytology preparations of 53 cases were prepared and presented on a website. Gunshot injuries to the paranasal sinuses and orbita are uncommon. Cisplatinum-based chemotherapy was effective as two of four relapsed patients survived tumor free. Therefore, EH cells may be functionally related to the output of a forward internal model thought to construct an efference copy of the actual eye movement. It has been proved that the inferior vena cava was permeable in 6 of the 7 controlled patients. Significant myocardial scar in the posterolateral left ventricle (LV) has been associated with a diminished response to cardiac resynchronization therapy (CRT) in patients with coronary artery disease, but the effects of resting perfusion abnormalities in nonischemic cardiomyopathy (NICM) are yet to be described. Nasal carriage of community-acquired Staphylococcus aureus and drug sensitivity tests in healthy children in Chengdu.

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